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The Journal of Immunology, 2003, 171: 5663-5667.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Increased NK Cell Activity in HIV-1-Exposed but Uninfected Vietnamese Intravascular Drug Users 1

Daniel Scott-Algara2,*, Lien X. Truong{dagger}, Pierre Versmisse*, Annie David*, Tram T. Luong{dagger}, Ngai V. Nguyen{ddagger}, Ioannis Theodorou§, Françoise Barré-Sinoussi* and Gianfranco Pancino*

* Unité de Biologie des Rétrovirus, Institut Pasteur, Paris, France; {dagger} Institut Pasteur and {ddagger} Hôpital Binh Trieu, Ho Chi Minh City, Vietnam; and § Laboratoire d’Immunologie Cellulaire et Tissulaire, Institut National de la Santé et de la Recherche Médicale Unité 543, Hôpital Pitié-Salpêtrière, Paris, France

We addressed the role of innate immunity in the protection against HIV-1 infection by studying NK cell function in 37 Vietnamese intravascular drug users (IDUs), who appeared to remain HIV-1 uninfected despite many years of high-risk exposure (exposed uninfected, EU), 10 IDUs who underwent seroconversion and 28 unexposed blood donors. Main results were: NK cell lytic activities against both the NK-susceptible K562 cell line and the NK-resistant Daudi cell line were significantly augmented in EU IDUs compared with either controls or seroconverters before or after seroconversion; NK cells producing the cytokines IFN-{gamma} and TNF-{alpha} and the {beta} chemokines CCL3, CCL4, and CCL5 were also increased in the EU IDUs, either after in vitro activation or without stimulation. The finding of an enhanced NK cell function in EU IDUs, especially compared with IDUs who became HIV-1 infected, supports the hypothesis that NK cells contribute to the protection against HIV-1 infection.




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