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-Chain in NK Cell Development and Ly-49 Induction 1
Departments of
*
Pathology and
Medicine, University of Chicago, Chicago, IL 60637
IL-15R
-deficient (IL-15R-/-) mice lack NK cells. However, when bone marrow (BM) progenitors from IL-15R-/- mice were cultured with IL-7, stem cell factor and flt3 ligand, followed by IL-15, they were able to differentiate into functional NK cells, indicating that IL-15R is not critical for NK cell development. Whereas NK cells generated in vitro from IL-15R-/- BM progenitors expressed CD94/NKG2, they failed to express Ly-49 receptors. In keeping with this, when IL-15R-/- BM cells were transferred into wild type recipients, they gave rise to NK cells in vivo, but with greatly reduced expression of Ly-49 receptors. Furthermore, the small numbers of NK cells found in IL-15-/- as well as IL-15R-/- but not flt3 ligand-/- mice expressed much lower levels of Ly-49 receptors than those from wild type mice. These results indicate a novel role for IL-15R-chain in Ly-49 induction on developing NK cells.
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