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The Journal of Immunology, 2003, 171: 4979-4983.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: {gamma}{delta} T Cells Provide Help to B Cells with Altered Clonotypes and Are Capable of Inducing Ig Gene Hypermutation1

Biao Zheng2, Ekaterina Marinova, Jin Han, Tse-Hua Tan and Shuhua Han

Department of Immunology, Baylor College of Medicine, Houston, TX 77030

It has not been resolved whether {gamma}{delta} T cells can collaborate with germinal center B cells and support Ig hypermutation during an Ab response to a truly defined T-dependent Ag. In this study, we show that in the absence of {alpha}{beta} T cells, immunization with the well-defined T-dependent Ag, (4-hydroxy-3-nitrophenyl) acetyl (NP) conjugate, was able to induce Ig hypermutation. However, the clonotypes of B cells responding to NP were dramatically altered in TCR {beta}-/- mice. Unlike B cells in wild-type mice that use canonical VDJ rearrangements, most NP-responding B cells in mutant mice use analog genes of the J558 gene family. In addition, the majority of anti-NP Abs produced in mutant mice use {kappa}L chain instead of {lambda}1L chain, which dominates in mice of Ighb background. Thus, the B cell population that collaborates with {gamma}{delta} T cells is distinct from B cells interacting with conventional {alpha}{beta} Th cells.


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The JI 2003 171: 4957-4958. [Full Text]  



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