| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; and
Division of Endocrinology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, United Kingdom
TNF-
release and action are central in the pathogenesis of the local and systemic inflammatory responses that occur after intestinal reperfusion. In this study we examined whether IL-1 participated in the cascade of events leading to TNF- production and TNF--mediated injury following reperfusion of the ischemic superior mesenteric artery in rats. Blockade of the action of IL-1 by the use of anti-IL-1 antiserum or administration of IL-1R antagonist (IL-1ra), a natural antagonist of IL-1Rs, resulted in marked enhancement of reperfusion-associated tissue injury, TNF- expression, and lethality. In contrast, there was marked decrease in IL-10 production. Facilitation of IL-1 action by administration of anti-IL-1ra, which antagonizes endogenous IL-1ra, or exogenous administration of rIL-1
suppressed reperfusion-induced tissue pathology, TNF- production, and lethality, but increased IL-10 production. Exogenous administration of IL-10 was effective in preventing the increase in tissue or plasma levels of TNF-, the exacerbated tissue injury, and lethality. An opposite effect was observed after treatment with anti-IL-10, demonstrating a role for endogenous production of IL-10 in modulating exacerbated reperfusion-associated tissue pathology and lethality. Finally, pretreatment with anti-IL-10 reversed the protective effect of IL-1 on reperfusion-associated lethality. Thus, IL-1 plays a major role in driving endogenous IL-10 production and protects against the TNF--dependent systemic and local acute inflammatory response following intestinal reperfusion injury.
This article has been cited by other articles:
|
|
 |
|
  B Stoffels, J Schmidt, A Nakao, A Nazir, R S Chanthaphavong, and A J Bauer Role of interleukin 10 in murine postoperative ileus Gut, May 1, 2009; 58(5): 648 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Souza, C. T. Fagundes, F. A. Amaral, D. Cisalpino, L. P. Sousa, A. T. Vieira, V. Pinho, J. R. Nicoli, L. Q. Vieira, I. M. Fierro, et al. The Required Role of Endogenously Produced Lipoxin A4 and Annexin-1 for the Production of IL-10 and Inflammatory Hyporesponsiveness in Mice J. Immunol., December 15, 2007; 179(12): 8533 - 8543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Fagundes, F. A. Amaral, A. L. S. Souza, A. T. Vieira, D. Xu, F. Y. Liew, D. G. Souza, and M. M. Teixeira ST2, an IL-1R family member, attenuates inflammation and lethality after intestinal ischemia and reperfusion J. Leukoc. Biol., February 1, 2007; 81(2): 492 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Connor, A. Harkin, and J. P. Kelly Methylenedioxymethamphetamine Suppresses Production of the Proinflammatory Cytokine Tumor Necrosis Factor-{alpha} Independent of a {beta}-Adrenoceptor-Mediated Increase in Interleukin-10 J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 134 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Souza, E. S. L. Lomez, V. Pinho, J. B. Pesquero, M. Bader, J. L. Pesquero, and M. M. Teixeira Role of Bradykinin B2 and B1 Receptors in the Local, Remote, and Systemic Inflammatory Responses That Follow Intestinal Ischemia and Reperfusion Injury J. Immunol., February 15, 2004; 172(4): 2542 - 2548. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
