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The Journal of Immunology, 2003, 170: 4437-4440.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-11

Christopher M. Smith*, Gabrielle T. Belz{dagger}, Nicholas S. Wilson*, Jose A. Villadangos{dagger}, Ken Shortman{dagger}, Francis R. Carbone{ddagger} and William R. Heath2,{dagger}

* Cooperative Research Center for Vaccine Technology and {dagger} Division of Immunology, Walter and Eliza Hall Institute of Medical Research, and {ddagger} Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia

CTL play a major role in immunity to HSV type 1, but little is known about the priming process. In this study, we have examined the class I-restricted presentation of an immunodominant determinant from HSV-1 glycoprotein B after footpad infection. We have found that the only cell types capable of presenting this determinant in draining popliteal lymph nodes within the first 3 days after infection are the CD11c+CD8{alpha}+CD45RA- dendritic cells. Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8{alpha}+ dendritic cells are the key subset involved in CTL immunity to this virus.




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