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TCR V8⁺ T Cells Prevent Development of Toxoplasmic Encephalitis in BALB/c Mice Genetically Resistant to the Disease¹

Hoil Kang^2,*,, Oliver Liesenfeld^3,*,, Jack S. Remington^*,, Jennifer Claflin, Xisheng Wang and Yasuhiro Suzuki^4,*,,

^* Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305; Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301; and Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061

BALB/c are genetically resistant to development of toxoplasmic encephalitis (TE) when infected with Toxoplasma gondii, whereas CBA/Ca mice are susceptible. We compared TCR V chain usage in lymphocytes infiltrated into brains between these animals following infection. TCR V8⁺ cells were the most frequent T cell population in brains of infected, resistant BALB/c mice, whereas TCR V6⁺ T cells were more prevalent than V8⁺ T cells in brains of infected, susceptible CBA/Ca mice. Adoptive transfer of V8⁺ immune T cells, obtained from infected BALB/c mice, prevented development of TE and mortality in infected athymic nude mice that lack T cells. In contrast, adoptive transfer of V6⁺ immune T cells did not prevent development of TE or mortality in the nude mice. The protective activity of V8⁺ immune T cells was greater than that of the total V8^- population. In addition, V8⁺ immune T cells produced markedly greater amounts of IFN- than did the V8^- population after stimulation with tachyzoite lysate Ags in vitro. Thus, V8⁺ T cells appear to play a crucial role in the genetic resistance of BALB/c mice against development of TE.

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				V. B. Carruthers and Y. Suzuki Effects of Toxoplasma gondii Infection on the Brain Schizophr Bull, May 1, 2007; 33(3): 745 - 751. [Abstract] [Full Text] [PDF]