| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-Dependent Mechanism1
* Department of Emergency Medicine, North Shore University Hospital-New York University School of Medicine; and
Center of Immunology and Inflammation, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030
We recently discovered that a ubiquitous protein, high mobility group box 1 protein (HMGB1), is released by activated macrophages, and functions as a late mediator of lethal systemic inflammation. To elucidate mechanisms underlying the regulation of HMGB1 release, we examined the roles of other cytokines in induction of HMGB1 release in macrophage cell cultures. Macrophage migration inhibitory factor, macrophage-inflammatory protein 1
, and IL-6 each failed to significantly induce the release of HMGB1 even at supraphysiological levels (up to 200 ng/ml). IFN-
, an immunoregulatory cytokine known to mediate the innate immune response, dose-dependently induced the release of HMGB1, TNF, and NO, but not other cytokines such as IL-1
, IL-1, or IL-6. Pharmacological suppression of TNF activity with neutralizing Abs, or genetic disruption of TNF expression (TNF knockout) partially (50–60%) inhibited IFN--mediated HMGB1 release. AG490, a specific inhibitor for Janus kinase 2 of the IFN- signaling pathway, dose-dependently attenuated IFN--induced HMGB1 release. These data suggest that IFN- plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism.
This article has been cited by other articles:
|
|
 |
|
  J.-H. Kim, S.-J. Kim, I.-S. Lee, M.-S. Lee, S. Uematsu, S. Akira, and K. I. Oh Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-{beta} Signaling Pathway J. Immunol., February 15, 2009; 182(4): 2458 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thapa and D. J. J. Carr Herpes Simplex Virus Type 2-Induced Mortality following Genital Infection Is Blocked by Anti-Tumor Necrosis Factor Alpha Antibody in CXCL10-Deficient Mice J. Virol., October 15, 2008; 82(20): 10295 - 10301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vila-del Sol, C. Punzon, and M. Fresno IFN-{gamma}-Induced TNF-{alpha} Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages J. Immunol., October 1, 2008; 181(7): 4461 - 4470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Fink Neuropeptide Modulators of High Mobility Group Box 1 Secretion as Potential Therapeutic Agents for Severe Sepsis Am. J. Pathol., May 1, 2008; 172(5): 1171 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Coffey, J. H. Wang, R. Kelly, L. Romics Jr., A. O'Callaghan, C. Fiuza, and H. P. Redmond Tolerization with BLP down-regulates HMGB1 a critical mediator of sepsis-related lethality J. Leukoc. Biol., October 1, 2007; 82(4): 906 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tang, R. Kang, W. Xiao, H. Wang, S. K. Calderwood, and X. Xiao The Anti-inflammatory Effects of Heat Shock Protein 72 Involve Inhibition of High-Mobility-Group Box 1 Release and Proinflammatory Function in Macrophages J. Immunol., July 15, 2007; 179(2): 1236 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ito, J. Fukazawa, and M. Yoshida Post-translational Methylation of High Mobility Group Box 1 (HMGB1) Causes Its Cytoplasmic Localization in Neutrophils J. Biol. Chem., June 1, 2007; 282(22): 16336 - 16344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tang, R. Kang, W. Xiao, L. Jiang, M. Liu, Y. Shi, K. Wang, H. Wang, and X. Xiao Nuclear Heat Shock Protein 72 as a Negative Regulator of Oxidative Stress (Hydrogen Peroxide)-Induced HMGB1 Cytoplasmic Translocation and Release J. Immunol., June 1, 2007; 178(11): 7376 - 7384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jiang, C. W. Bell, and D. S. Pisetsky The Relationship between Apoptosis and High-Mobility Group Protein 1 Release from Murine Macrophages Stimulated with Lipopolysaccharide or Polyinosinic-Polycytidylic Acid J. Immunol., May 15, 2007; 178(10): 6495 - 6503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Tellides and J. S. Pober Interferon-{gamma} Axis in Graft Arteriosclerosis Circ. Res., March 16, 2007; 100(5): 622 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Li, J. Li, M. Ashok, R. Wu, D. Chen, L. Yang, H. Yang, K. J. Tracey, P. Wang, A. E. Sama, et al. A Cardiovascular Drug Rescues Mice from Lethal Sepsis by Selectively Attenuating a Late-Acting Proinflammatory Mediator, High Mobility Group Box 1 J. Immunol., March 15, 2007; 178(6): 3856 - 3864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Tang, Y. Shi, R. Kang, T. Li, W. Xiao, H. Wang, and X. Xiao Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1 J. Leukoc. Biol., March 1, 2007; 81(3): 741 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, Q. Chen, H. Yang, K. J. Tracey, M. Bustin, and J. J. Oppenheim High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin J. Leukoc. Biol., January 1, 2007; 81(1): 59 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Urbonaviciute, B. G. Furnrohr, C. Weber, M. Haslbeck, S. Wilhelm, M. Herrmann, and R. E. Voll Factors masking HMGB1 in human serum and plasma J. Leukoc. Biol., January 1, 2007; 81(1): 67 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wahamaa, T. Vallerskog, S. Qin, C. Lunderius, G. LaRosa, U. Andersson, and H. E. Harris HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay J. Leukoc. Biol., January 1, 2007; 81(1): 129 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vila-del Sol, M. D. Diaz-Munoz, and M. Fresno Requirement of tumor necrosis factor {alpha} and nuclear factor-{kappa}B in the induction by IFN-{gamma} of inducible nitric oxide synthase in macrophages J. Leukoc. Biol., January 1, 2007; 81(1): 272 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mor-Vaknin, A. Punturieri, K. Sitwala, N. Faulkner, M. Legendre, M. S. Khodadoust, F. Kappes, J. H. Ruth, A. Koch, D. Glass, et al. The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor Mol. Cell. Biol., December 15, 2006; 26(24): 9484 - 9496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Youn and J.-S. Shin Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion J. Immunol., December 1, 2006; 177(11): 7889 - 7897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Bell, W. Jiang, C. F. Reich III, and D. S. Pisetsky The extracellular release of HMGB1 during apoptotic cell death Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1318 - C1325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jiang and D. S. Pisetsky The Role of IFN-{alpha} and Nitric Oxide in the Release of HMGB1 by RAW 264.7 Cells Stimulated with Polyinosinic-Polycytidylic Acid or Lipopolysaccharide. J. Immunol., September 1, 2006; 177(5): 3337 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, D. B. Stolz, P. L. Sappington, C. A. Macias, M. E. Killeen, J. J. Tenhunen, R. L. Delude, and M. P. Fink HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers Am J Physiol Cell Physiol, April 1, 2006; 290(4): C990 - C999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Killeen, J. A. Englert, D. B. Stolz, M. Song, Y. Han, R. L. Delude, J. A. Kellum, and M. P. Fink The Phase 2 Enzyme Inducers Ethacrynic Acid, DL-Sulforaphane, and Oltipraz Inhibit Lipopolysaccharide-Induced High-Mobility Group Box 1 Secretion by RAW 264.7 Cells J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1070 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, W. Li, J. Li, B. Rendon-Mitchell, M. Ochani, M. Ashok, L. Yang, H. Yang, K. J. Tracey, P. Wang, et al. The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica sinensis, Protects Mice against Lethal Endotoxemia and Sepsis J. Nutr., February 1, 2006; 136(2): 360 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jiang, J. Li, M. Gallowitsch-Puerta, K. J. Tracey, and D. S. Pisetsky The effects of CpG DNA on HMGB1 release by murine macrophage cell lines J. Leukoc. Biol., October 1, 2005; 78(4): 930 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yang, H. Wang, C. J. Czura, and K. J. Tracey The cytokine activity of HMGB1 J. Leukoc. Biol., July 1, 2005; 78(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E. Dumitriu, P. Baruah, B. Valentinis, R. E. Voll, M. Herrmann, P. P. Nawroth, B. Arnold, M. E. Bianchi, A. A. Manfredi, and P. Rovere-Querini Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products J. Immunol., June 15, 2005; 174(12): 7506 - 7515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shirota, I. Gursel, M. Gursel, and D. M. Klinman Suppressive Oligodeoxynucleotides Protect Mice from Lethal Endotoxic Shock J. Immunol., April 15, 2005; 174(8): 4579 - 4583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chen, J. Li, X. Qiang, C. J. Czura, M. Ochani, K. Ochani, L. Ulloa, H. Yang, K. J. Tracey, P. Wang, et al. Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis J. Lipid Res., April 1, 2005; 46(4): 623 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vila-del Sol and M. Fresno Involvement of TNF and NF-{kappa}B in the Transcriptional Control of Cyclooxygenase-2 Expression by IFN-{gamma} in Macrophages J. Immunol., March 1, 2005; 174(5): 2825 - 2833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takagi, M. Takagi, S. Kanangat, K. J. Warrington, H. Shigemitsu, and A. E. Postlethwaite Modulation of TNF-{alpha} Gene Expression by IFN-{gamma} and Pamidronate in Murine Macrophages: Regulation by STAT1-Dependent Pathways J. Immunol., February 15, 2005; 174(4): 1801 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kalinina, A. Agrotis, Y. Antropova, G. DiVitto, P. Kanellakis, G. Kostolias, O. Ilyinskaya, E. Tararak, and A. Bobik Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions: Role of Activated Macrophages and Cytokines Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2320 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chen, J. Li, M. Ochani, B. Rendon-Mitchell, X. Qiang, S. Susarla, L. Ulloa, H. Yang, S. Fan, S. M. Goyert, et al. Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms J. Leukoc. Biol., November 1, 2004; 76(5): 994 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rouhiainen, J. Kuja-Panula, E. Wilkman, J. Pakkanen, J. Stenfors, R. K. Tuominen, M. Lepantalo, O. Carpen, J. Parkkinen, and H. Rauvala Regulation of monocyte migration by amphoterin (HMGB1) Blood, August 15, 2004; 104(4): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jiang and D. S. Pisetsky The Effect of Dexamethasone on the Generation of Plasma DNA from Dead and Dying Cells Am. J. Pathol., May 1, 2004; 164(5): 1751 - 1759. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
