| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
Departments of
*
Medicine and
Microbiology, Immunology, and Molecular Genetics,
Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
Institute for Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany; and
¶ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110
Triggering receptor expressed on myeloid cells (TREM)-1 is a cell surface molecule expressed on neutrophils and monocytes implicated in the propagation of the inflammatory response. To further characterize the function of this molecule in different phases of the immune response, we examined TREM-1 in the context of host defense against microbial pathogens. In primary human monocytes TREM-1 activation did not trigger innate antimicrobial pathways directed against intracellular Mycobacterium tuberculosis, and only minimally improved phagocytosis. However, activation of TREM-1 on monocytes did drive robust production of proinflammatory chemokines such as macrophage inflammatory protein-1
and IL-8. Engagement of TREM-1 in combination with microbial ligands that activate Toll-like receptors also synergistically increased production of the proinflammatory cytokines TNF- and GM-CSF, while inhibiting production of IL-10, an anti-inflammatory cytokine. Expression of TREM-1 was up-regulated in response to TLR activation, an effect further enhanced by GM-CSF and TNF- but inhibited by IL-10. Functionally, primary monocytes differentiated into immature dendritic cells following activation through TREM-1, evidenced by higher expression of CD1a, CD86, and MHC class II molecules. These cells had an improved ability to elicit T cell proliferation and production of IFN-
. Our data suggest that activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges.
This article has been cited by other articles:
|
|
 |
|
  C E Collins, D T La, H-T Yang, F Massin, S Gibot, G Faure, and W Stohl Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis Ann Rheum Dis, November 1, 2009; 68(11): 1768 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kuai, B. Gregory, A. Hill, D. D. Pittman, J. L. Feldman, T. Brown, B. Carito, M. O'Toole, R. Ramsey, O. Adolfsson, et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines Rheumatology, November 1, 2009; 48(11): 1352 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Youssef, M. A. Ledingham, S. S. Bollapragada, N. O'Gorman, F. Jordan, A. Young, and J. E. Norman The Role of Toll-Like Receptors (TLR-2 and -4) and Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) in Human Term and Preterm Labor Reproductive Sciences, September 1, 2009; 16(9): 843 - 856. [Abstract] [PDF]
|
|
|
|
 |
|
 C.-C. Ho, W.-Y. Liao, C.-Y. Wang, Y.-H. Lu, H.-Y. Huang, H.-Y. Chen, W.-K. Chan, H.-W. Chen, and P.-C. Yang TREM-1 Expression in Tumor-associated Macrophages and Clinical Outcome in Lung Cancer Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 763 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dower, D. K. Ellis, K. Saraf, S. A. Jelinsky, and L.-L. Lin Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide J. Immunol., March 1, 2008; 180(5): 3520 - 3534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ornatowska, A. C. Azim, X. Wang, J. W. Christman, L. Xiao, M. Joo, and R. T. Sadikot Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages Am J Physiol Lung Cell Mol Physiol, December 1, 2007; 293(6): L1377 - L1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Klesney-Tait and M. Colonna Uncovering the TREM-1-TLR connection Am J Physiol Lung Cell Mol Physiol, December 1, 2007; 293(6): L1374 - L1376. [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, H. Kohsaka, H. Kitasato, and T. Akahoshi Lipopolysaccharide-Induced Up-Regulation of Triggering Receptor Expressed on Myeloid Cells-1 Expression on Macrophages Is Regulated by Endogenous Prostaglandin E2 J. Immunol., January 15, 2007; 178(2): 1144 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Fortin, O. Lesur, and T. Fulop Jr Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4 Int. Immunol., January 1, 2007; 19(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Netea, T. Azam, G. Ferwerda, S. E. Girardin, S.-H. Kim, and C. A. Dinarello Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors J. Leukoc. Biol., December 1, 2006; 80(6): 1454 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Phua, E. S. C. Koay, D. Zhang, L. K. Tai, X. L. Boo, K. C. Lim, and T. K. Lim Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections Eur. Respir. J., October 1, 2006; 28(4): 695 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Bosco, M. Puppo, C. Santangelo, L. Anfosso, U. Pfeffer, P. Fardin, F. Battaglia, and L. Varesio Hypoxia Modifies the Transcriptome of Primary Human Monocytes: Modulation of Novel Immune-Related Genes and Identification Of CC-Chemokine Ligand 20 as a New Hypoxia-Inducible Gene J. Immunol., August 1, 2006; 177(3): 1941 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gibot, C. Buonsanti, F. Massin, M. Romano, M.-N. Kolopp-Sarda, F. Benigni, G. C. Faure, M.-C. Bene, P. Panina-Bordignon, N. Passini, et al. Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Infect. Immun., May 1, 2006; 74(5): 2823 - 2830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Mahdy, D. A. Lowes, H. F. Galley, J. E. Bruce, and N. R. Webster Production of Soluble Triggering Receptor Expressed on Myeloid Cells by Lipopolysaccharide-Stimulated Human Neutrophils Involves De Novo Protein Synthesis Clin. Vaccine Immunol., April 1, 2006; 13(4): 492 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Merck, C. Gaillard, M. Scuiller, P. Scapini, M. A. Cassatella, G. Trinchieri, and E. E. M. Bates Ligation of the FcR{gamma} Chain-Associated Human Osteoclast-Associated Receptor Enhances the Proinflammatory Responses of Human Monocytes and Neutrophils. J. Immunol., March 1, 2006; 176(5): 3149 - 3156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Carpenter, K. F. Buckland, Z. Xing, and C. M. Hogaboam Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis Infect. Immun., December 1, 2005; 73(12): 8402 - 8406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Merck, B. de Saint-Vis, M. Scuiller, C. Gaillard, C. Caux, G. Trinchieri, and E. E. M. Bates Fc receptor {gamma}-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses Blood, May 1, 2005; 105(9): 3623 - 3632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schenk, A. Bouchon, S. Birrer, M. Colonna, and C. Mueller Macrophages Expressing Triggering Receptor Expressed on Myeloid Cells-1 Are Underrepresented in the Human Intestine J. Immunol., January 1, 2005; 174(1): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Knapp, S. Gibot, A. de Vos, H. H. Versteeg, M. Colonna, and T. van der Poll Cutting Edge: Expression Patterns of Surface and Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Human Endotoxemia J. Immunol., December 15, 2004; 173(12): 7131 - 7134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gibot, M.-N. Kolopp-Sarda, M.-C. Bene, P.-E. Bollaert, A. Lozniewski, F. Mory, B. Levy, and G. C. Faure A Soluble Form of the Triggering Receptor Expressed on Myeloid Cells-1 Modulates the Inflammatory Response in Murine Sepsis J. Exp. Med., December 6, 2004; 200(11): 1419 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Washington, R. L. Schubert, L. Quigley, T. Disipio, R. Feltz, E. H. Cho, and D. W. McVicar A TREM family member, TLT-1, is found exclusively in the {alpha}-granules of megakaryocytes and platelets Blood, August 15, 2004; 104(4): 1042 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Richeldi, M. Mariani, M. Losi, F. Maselli, L. Corbetta, C. Buonsanti, M. Colonna, F. Sinigaglia, P. Panina-Bordignon, and L.M. Fabbri Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections Eur. Respir. J., August 1, 2004; 24(2): 247 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gibot, M.-N. Kolopp-Sarda, M. C. Bene, A. Cravoisy, B. Levy, G. C. Faure, and P.-E. Bollaert Plasma Level of a Triggering Receptor Expressed on Myeloid Cells-1: Its Diagnostic Accuracy in Patients with Suspected Sepsis Ann Intern Med, July 6, 2004; 141(1): 9 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Aoki, A. Zganiacz, P. Margetts, and Z. Xing Differential Regulation of DAP12 and Molecules Associated with DAP12 during Host Responses to Mycobacterial Infection Infect. Immun., May 1, 2004; 72(5): 2477 - 2483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Radsak, H. R. Salih, H.-G. Rammensee, and H. Schild Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival J. Immunol., April 15, 2004; 172(8): 4956 - 4963. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
