| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304
IgA immunoblasts can seed both intestinal and nonintestinal mucosal sites following localized mucosal immunization, an observation that has led to the concept of a common mucosal immune system. In this study, we demonstrate that the mucosae-associated epithelial chemokine, MEC (CCL28), which is expressed by epithelia in diverse mucosal tissues, is selectively chemotactic for IgA Ab-secreting cells (ASC): MEC attracts IgA- but not IgG- or IgM-producing ASC from both intestinal and nonintestinal lymphoid and effector tissues, including the intestines, lungs, and lymph nodes draining the bronchopulmonary tree and oral cavity. In contrast, the small intestinal chemokine, TECK (CCL25), attracts an overlapping subpopulation of IgA ASC concentrated in the small intestines and its draining lymphoid tissues. Surprisingly, T cells from mucosal sites fail to respond to MEC. These findings suggest a broad and unifying role for MEC in the physiology of the mucosal IgA immune system.
This article has been cited by other articles:
|
|
 |
|
  M. Hansson, M. Hermansson, H. Svensson, A. Elfvin, L.-E. Hansson, E. Johnsson, A. Sjoling, and M. Quiding-Jarbrink CCL28 Is Increased in Human Helicobacter pylori-Induced Gastritis and Mediates Recruitment of Gastric Immunoglobulin A-Secreting Cells Infect. Immun., July 1, 2008; 76(7): 3304 - 3311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Germanov, L. Veinotte, R. Cullen, E. Chamberlain, E. C. Butcher, and B. Johnston Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells J. Immunol., July 1, 2008; 181(1): 81 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Shirakawa, D. Nagakubo, K. Hieshima, T. Nakayama, Z. Jin, and O. Yoshie 1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells J. Immunol., March 1, 2008; 180(5): 2786 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Ruiz-Arguello, V. P. Smith, G. S. V. Campanella, F. Baleux, F. Arenzana-Seisdedos, A. D. Luster, and A. Alcami An Ectromelia Virus Protein That Interacts with Chemokines through Their Glycosaminoglycan Binding Domain J. Virol., January 15, 2008; 82(2): 917 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Hermsen, F. E. Gomez, Y. Maeshima, Y. Sano, W. Kang, and K. A. Kudsk Decreased Enteral Stimulation Alters Mucosal Immune Chemokines JPEN J Parenter Enteral Nutr, January 1, 2008; 32(1): 36 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Di Martino, C. Basset, A. Ogier, A. Charpilienne, D. Poncet, and E. Kohli Distribution and phenotype of rotavirus-specific B cells induced during the antigen-driven primary response to 2/6 virus-like particles administered by the intrarectal and the intranasal routes J. Leukoc. Biol., October 1, 2007; 82(4): 821 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.X. Lu and R.S. Jacobson Oral Mucosal Immunity and HIV/SIV Infection J. Dent. Res., March 1, 2007; 86(3): 216 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Eksteen, A. Miles, S. M. Curbishley, C. Tselepis, A. J. Grant, L. S. K. Walker, and D. H. Adams Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10 J. Immunol., July 1, 2006; 177(1): 593 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Feng, M. C. Jaimes, N. H. Lazarus, D. Monak, C. Zhang, E. C. Butcher, and H. B. Greenberg Redundant Role of Chemokines CCL25/TECK and CCL28/MEC in IgA+ Plasmablast Recruitment to the Intestinal Lamina Propria After Rotavirus Infection J. Immunol., May 15, 2006; 176(10): 5749 - 5759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alejo, M. B. Ruiz-Arguello, Y. Ho, V. P. Smith, M. Saraiva, and A. Alcami A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus PNAS, April 11, 2006; 103(15): 5995 - 6000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ogawa, M. Iimura, L. Eckmann, and M. F. Kagnoff Regulated production of the chemokine CCL28 in human colon epithelium Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G1062 - G1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Jaimes, O. L. Rojas, E. J. Kunkel, N. H. Lazarus, D. Soler, E. C. Butcher, D. Bass, J. Angel, M. A. Franco, and H. B. Greenberg Maturation and Trafficking Markers on Rotavirus-Specific B Cells during Acute Infection and Convalescence in Children J. Virol., October 15, 2004; 78(20): 10967 - 10976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Wilson and E. C. Butcher CCL28 Controls Immunoglobulin (Ig)A Plasma Cell Accumulation in the Lactating Mammary Gland and IgA Antibody Transfer to the Neonate J. Exp. Med., September 20, 2004; 200(6): 805 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hieshima, Y. Kawasaki, H. Hanamoto, T. Nakayama, D. Nagakubo, A. Kanamaru, and O. Yoshie CC Chemokine Ligands 25 and 28 Play Essential Roles in Intestinal Extravasation of IgA Antibody-Secreting Cells J. Immunol., September 15, 2004; 173(6): 3668 - 3675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Underhill, K. P. Kolli, and G. S. Kansas Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation Blood, December 1, 2003; 102(12): 4076 - 4083. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
