The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, L. X.
Right arrow Articles by Dubinett, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, L. X.
Right arrow Articles by Dubinett, S. M.
The Journal of Immunology, 2003, 170: 3585-3591.
Copyright © 2003 by The American Association of Immunologists

IL-10 Mediates Sigma1 Receptor-Dependent Suppression of Antitumor Immunity1

Li X. Zhu{dagger}, Sherven Sharma{dagger},{ddagger}, Brian Gardner{dagger},{ddagger}, Brian Escuadro{dagger}, Kimberly Atianzar{dagger}, Donald P. Tashkin*,{dagger} and Steven M. Dubinett2,*,{dagger},{ddagger}

* University of California Los Angeles Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095; {dagger} Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and {ddagger} Division of Pulmonary and Critical Care Medicine, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA 90073

Sigma receptors are unique endoplasmic reticulum proteins that mediate signaling for a variety of drugs. We determined the effect of sigma1 receptor agonists on immune responses in a syngeneic lung cancer model. Sigma1 receptor agonists, including cocaine, up-regulated splenocyte IL-10 mRNA and protein production in vitro in a sigma receptor-dependent, pertussis toxin-sensitive manner. In vivo, sigma1 receptor agonists promoted tumor growth and induced IL-10 at the tumor site. Increased tumor growth was prevented by administration of specific Abs to IL-10 or by administration of specific sigma1 receptor antagonists. We report that sigma1 receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism.


Related articles in The JI:

IN THIS ISSUE

The JI 2003 170: 3449-3450. [Full Text]  



This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
M. D. Roth, K. M. Whittaker, R. Choi, D. P. Tashkin, and G. C. Baldwin
Cocaine and {sigma}-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model
J. Leukoc. Biol., December 1, 2005; 78(6): 1198 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. S. Kang and P. M. Allen
Priming in the Presence of IL-10 Results in Direct Enhancement of CD8+ T Cell Primary Responses and Inhibition of Secondary Responses
J. Immunol., May 1, 2005; 174(9): 5382 - 5389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Li, A. L. Carr, E. J. Donald, J. J. Skitzki, R. Okuyama, L. M. Stoolman, and A. E. Chang
Synergistic Effects of IL-12 and IL-18 in Skewing Tumor-Reactive T-Cell Responses Towards a Type 1 Pattern
Cancer Res., February 1, 2005; 65(3): 1063 - 1070.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.