| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pathology and Microbiology, University of Nebraska Medical Center, 987660 Nebraska Medical Center, Omaha, NE 68198
IL-8, a member of the chemokine family, has been shown to play an important role in tumor growth, angiogenesis, and metastasis. The objective of this study was to determine the mechanism of IL-8-mediated angiogenesis. We examined the direct role of IL-8 in angiogenesis by examining IL-8 receptor expression on endothelial cells and their proliferation, survival, and matrix metalloproteinases (MMPs) production. We demonstrate that HUVEC and human dermal microvascular endothelial cells constitutively express CXCR1 and CXCR2 mRNA and protein. Recombinant human IL-8 induced endothelial cell proliferation and capillary tube organization while neutralization of IL-8 by anti-IL-8 Ab blocks IL-8-mediated capillary tube organization. Incubation of endothelial cells with IL-8 inhibited endothelial cell apoptosis and enhanced antiapoptotic gene expression. Endothelial cells incubated with IL-8 had higher levels of Bcl-xL:Bcl-xS and Bcl-2:Bax ratios. Furthermore, incubation of endothelial cells with IL-8 up-regulated MMP-2 and MMP-9 production and mRNA expression. Our data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CXCR1- and CXCR2-expressing endothelial cells and regulated angiogenesis.
This article has been cited by other articles:
|
|
 |
|
  S. Madonna, C. Scarponi, O. De Pita, and C. Albanesi Suppressor of cytokine signaling 1 inhibits IFN-{gamma} inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation FASEB J, September 1, 2008; 22(9): 3287 - 3297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Movahedi, C. Gysemans, D. Jacobs-Tulleneers-Thevissen, C. Mathieu, and D. Pipeleers Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor Diabetes, August 1, 2008; 57(8): 2128 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Beswick and V. E. Reyes Macrophage Migration Inhibitory Factor and Interleukin-8 Produced by Gastric Epithelial Cells during Helicobacter pylori Exposure Induce Expression and Activation of the Epidermal Growth Factor Receptor Infect. Immun., July 1, 2008; 76(7): 3233 - 3240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Lurje, W. Zhang, A. M. Schultheis, D. Yang, S. Groshen, A. E. Hendifar, H. Husain, M. A. Gordon, F. Nagashima, H. M. Chang, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer Ann. Onc., June 11, 2008; (2008) mdn368v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.H. Nissim Ben Efraim and F. Levi-Schaffer Review: Tissue remodeling and angiogenesis in asthma: the role of the eosinophil Therapeutic Advances in Respiratory Disease, June 1, 2008; 2(3): 163 - 171. [Abstract] [PDF]
|
|
|
|
 |
|
 N. A. Abdel-Malak, C. B. Srikant, A. S. Kristof, S. A. Magder, J. A. Di Battista, and S. N. A. Hussain Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8 Blood, April 15, 2008; 111(8): 4145 - 4154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Scupoli, M. Donadelli, F. Cioffi, M. Rossi, O. Perbellini, G. Malpeli, S. Corbioli, F. Vinante, M. Krampera, M. Palmieri, et al. Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-{kappa}B and JNK/AP-1 pathways Haematologica, April 1, 2008; 93(4): 524 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Merritt, Y. G. Lin, W. A. Spannuth, M. S. Fletcher, A. A. Kamat, L. Y. Han, C. N. Landen, N. Jennings, K. De Geest, R. R. Langley, et al. Effect of Interleukin-8 Gene Silencing With Liposome-Encapsulated Small Interfering RNA on Ovarian Cancer Cell Growth J Natl Cancer Inst, March 5, 2008; 100(5): 359 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Petreaca, M. Yao, Y. Liu, K. DeFea, and M. Martins-Green Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability Mol. Biol. Cell, December 1, 2007; 18(12): 5014 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.-Y. Oh, C.-H. Yoon, J. Hur, J.-H. Kim, T.-Y. Kim, C.-S. Lee, K.-W. Park, I.-H. Chae, B.-H. Oh, Y.-B. Park, et al. Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle Blood, December 1, 2007; 110(12): 3891 - 3899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kanayasu-Toyoda, A. Ishii-Watabe, T. Suzuki, T. Oshizawa, and T. Yamaguchi A New Role of Thrombopoietin Enhancing ex Vivo Expansion of Endothelial Precursor Cells Derived from AC133-positive Cells J. Biol. Chem., November 16, 2007; 282(46): 33507 - 33514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Park, H.-J. Kwak, H.-C. Lee, D.-H. Yoo, I.-C. Park, M.-S. Kim, S.-H. Lee, C. H. Rhee, and S.-I. Hong Nerve Growth Factor Induces Endothelial Cell Invasion and Cord Formation by Promoting Matrix Metalloproteinase-2 Expression through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and AP-2 Transcription Factor J. Biol. Chem., October 19, 2007; 282(42): 30485 - 30496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D. Gross, J. O. Boyle, B. Du, V. D. Kekatpure, A. Lantowski, H. T. Thaler, B. B. Weksler, K. Subbaramaiah, and A. J. Dannenberg Inhibition of Jun NH2-Terminal Kinases Suppresses the Growth of Experimental Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., October 1, 2007; 13(19): 5910 - 5917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanchez, A. Moldobaeva, J. McClintock, J. Jenkins, and E. Wagner The role of CXCR2 in systemic neovascularization of the mouse lung J Appl Physiol, August 1, 2007; 103(2): 594 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Giorgini, D. Trisciuoglio, C. Gabellini, M. Desideri, L. Castellini, C. Colarossi, U. Zangemeister-Wittke, G. Zupi, and D. Del Bufalo Modulation of bcl-xL in Tumor Cells Regulates Angiogenesis through CXCL8 Expression Mol. Cancer Res., August 1, 2007; 5(8): 761 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. B. Levashova, N. Sharma, O. A. Timofeeva, J. S. Dome, and A. O. Perantoni ELR+-CXC Chemokines and Their Receptors in Early Metanephric Development J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2359 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Caselli, S. Fiorentini, C. Amici, D. Di Luca, A. Caruso, and M. G. Santoro Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-{kappa}B pathway Blood, April 1, 2007; 109(7): 2718 - 2726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wehner, C. N. Morrell, T. Reynolds, E. R. Rodriguez, and W. M. Baldwin III Antibody and Complement in Transplant Vasculopathy Circ. Res., February 2, 2007; 100(2): 191 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dell'Eva, C. Ambrosini, S. Minghelli, D. M. Noonan, A. Albini, and N. Ferrari The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-{kappa}B pathway Carcinogenesis, February 1, 2007; 28(2): 404 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Scaife, J. N. Bulmer, S. C. Robson, B. A. Innes, and R. F. Searle Effector Activity of Decidual CD8+ T Lymphocytes in Early Human Pregnancy Biol Reprod, October 1, 2006; 75(4): 562 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. McCord, S. I. Resto-Ruiz, and B. E. Anderson Autocrine Role for Interleukin-8 in Bartonella henselae-Induced Angiogenesis Infect. Immun., September 1, 2006; 74(9): 5185 - 5190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Zeitlin, E. Joo, Z. Dong, K. Warner, G. Wang, Z. Nikolovska-Coleska, S. Wang, and J. E. Nor Antiangiogenic Effect of TW37, a Small-Molecule Inhibitor of Bcl-2. Cancer Res., September 1, 2006; 66(17): 8698 - 8706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yao, R.-H. Zhou, M. Petreaca, L. Zheng, J. Shyy, and M. Martins-Green Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis J. Leukoc. Biol., September 1, 2006; 80(3): 608 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-Y. Bao, J. Yao, and Y.-F. Lee 1{alpha}, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis Carcinogenesis, September 1, 2006; 27(9): 1883 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Stamatovic, R. F. Keep, M. Mostarica-Stojkovic, and A. V. Andjelkovic CCL2 Regulates Angiogenesis via Activation of Ets-1 Transcription Factor J. Immunol., August 15, 2006; 177(4): 2651 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Lane, A. R. Anand, and R. K. Ganju Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis Int. Immunol., August 1, 2006; 18(8): 1315 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Eum, G. B. Rha, B. Hennig, and M. Toborek c-Src Is the Primary Signaling Mediator of Polychlorinated Biphenyl-Induced Interleukin-8 Expression in a Human Microvascular Endothelial Cell Line Toxicol. Sci., July 1, 2006; 92(1): 311 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. N. H. Masckauchan and J. Kitajewski Wnt/Frizzled Signaling in the Vasculature: New Angiogenic Factors in Sight Physiology, June 1, 2006; 21(3): 181 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Brown, D. Fallin, I. Ruczinski, A. Hutchinson, B. Staats, F. Vitale, C. Lauria, D. Serraino, G. Rezza, G. Mbisa, et al. Associations of Classic Kaposi Sarcoma with Common Variants in Genes that Modulate Host Immunity. Cancer Epidemiol. Biomarkers Prev., May 1, 2006; 15(5): 926 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Korherr, H. Gille, R. Schafer, K. Koenig-Hoffmann, J. Dixelius, K. A. Egland, I. Pastan, and U. Brinkmann Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. PNAS, March 14, 2006; 103(11): 4240 - 4245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dobreva, G. Waeber, R. W. James, and C. Widmann Interleukin-8 Secretion by Fibroblasts Induced by Low Density Lipoproteins Is p38 MAPK-dependent and Leads to Cell Spreading and Wound Closure J. Biol. Chem., January 6, 2006; 281(1): 199 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Charalambous, L. B. Pen, Y. S. Su, J. Milan, T. C. Chen, and F. M. Hofman Interleukin-8 Differentially Regulates Migration of Tumor-Associated and Normal Human Brain Endothelial Cells Cancer Res., November 15, 2005; 65(22): 10347 - 10354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-P. Lee, D.-I. Tai, K.-H. Lan, A. F.-Y. Li, H.-C. Hsu, E.-J. Lin, Y.-P. Lin, M.-L. Sheu, C.-P. Li, F.-Y. Chang, et al. The -251T Allele of the Interleukin-8 Promoter Is Associated with Increased Risk of Gastric Carcinoma Featuring Diffuse-Type Histopathology in Chinese Population Clin. Cancer Res., September 15, 2005; 11(18): 6431 - 6441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Yoon, J. Hur, K.-W. Park, J.-H. Kim, C.-S. Lee, I.-Y. Oh, T.-Y. Kim, H.-J. Cho, H.-J. Kang, I.-H. Chae, et al. Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells: The Role of Angiogenic Cytokines and Matrix Metalloproteinases Circulation, September 13, 2005; 112(11): 1618 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. He, T. E. Peterson, and Z. S. Katusic Paracrine mitogenic effect of human endothelial progenitor cells: role of interleukin-8 Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H968 - H972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shoshani, J. Pe'er, V. Doviner, J. Frucht-Pery, and A. Solomon Increased Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Pseudophakic Corneal Edema Invest. Ophthalmol. Vis. Sci., June 1, 2005; 46(6): 1940 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Murphy, M. McGurk, J. Pettigrew, A. Santinelli, R. Mazzucchelli, P. G. Johnston, R. Montironi, and D. J.J. Waugh Nonapical and Cytoplasmic Expression of Interleukin-8, CXCR1, and CXCR2 Correlates with Cell Proliferation and Microvessel Density in Prostate Cancer Clin. Cancer Res., June 1, 2005; 11(11): 4117 - 4127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Moldobaeva and E. M. Wagner Difference in proangiogenic potential of systemic and pulmonary endothelium: role of CXCR2 Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1117 - L1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Gallagher, Y. Bao, A. Prorock, P. Zigrino, R. Nischt, V. Politi, C. Mauch, B. Dragulev, and J. W. Fox Gene Expression Profiling Reveals Cross-talk between Melanoma and Fibroblasts: Implications for Host-Tumor Interactions in Metastasis Cancer Res., May 15, 2005; 65(10): 4134 - 4146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Brat, A. C. Bellail, and E. G. Van Meir The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis Neuro-oncol, April 1, 2005; 7(2): 122 - 133. [Abstract] [PDF]
|
|
|
|
|
|
R. Schruefer, N. Lutze, J. Schymeinsky, and B. Walzog Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8 Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1186 - H1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Galvez, L. Genis, S. Matias-Roman, S. A. Oblander, K. Tryggvason, S. S. Apte, and A. G. Arroyo Membrane Type 1-Matrix Metalloproteinase Is Regulated by Chemokines Monocyte-Chemoattractant Protein-1/CCL2 and Interleukin-8/CXCL8 in Endothelial Cells during Angiogenesis J. Biol. Chem., January 14, 2005; 280(2): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. M. Rao and U. R. Pendurthi Tissue Factor-Factor VIIa Signaling Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 47 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lefranc, T. Mijatovic, V. Mathieu, S. Rorive, C. Decaestecker, O. Debeir, J. Brotchi, P. Van Ham, I. Salmon, and R. Kiss Characterization of Gastrin-Induced Proangiogenic Effects In vivo in Orthotopic U373 Experimental Human Glioblastomas and In vitro in Human Umbilical Vein Endothelial Cells Clin. Cancer Res., December 15, 2004; 10(24): 8250 - 8265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. STRIETER, J. A. BELPERIO, M. D. BURDICK, S. SHARMA, S. M. DUBINETT, and M. P. KEANE CXC Chemokines: Angiogenesis, Immunoangiostasis, and Metastases in Lung Cancer Ann. N.Y. Acad. Sci., December 1, 2004; 1028(1): 351 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y H Yang, H J Lai, C M Huang, L C Wang, Y T Lin, and B L Chiang Sera from children with active Henoch-Schonlein purpura can enhance the production of interleukin 8 by human umbilical venous endothelial cells Ann Rheum Dis, November 1, 2004; 63(11): 1511 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Deem and J. M. Cook-Mills Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species Blood, October 15, 2004; 104(8): 2385 - 2393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Bobrovnikova-Marjon, P. L. Marjon, O. Barbash, D. L. Vander Jagt, and S. F. Abcouwer Expression of Angiogenic Factors Vascular Endothelial Growth Factor and Interleukin-8/CXCL8 Is Highly Responsive to Ambient Glutamine Availability: Role of Nuclear Factor-{kappa}B and Activating Protein-1 Cancer Res., July 15, 2004; 64(14): 4858 - 4869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Spruce, L. A. Campbell, N. McTavish, M. A. Cooper, M. V. L. Appleyard, M. O'Neill, J. Howie, J. Samson, S. Watt, K. Murray, et al. Small Molecule Antagonists of the {sigma}-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growth in Vitro and in Vivo Cancer Res., July 15, 2004; 64(14): 4875 - 4886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Motto ADAMTS-13, VWF, inflammation, and thrombosis Blood, July 1, 2004; 104(1): 4 - 5. [Full Text] [PDF]
|
|
|
|
|
|
A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow Blood, July 1, 2004; 104(1): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Hjortoe, L. C. Petersen, T. Albrektsen, B. B. Sorensen, P. L. Norby, S. K. Mandal, U. R. Pendurthi, and L. V. M. Rao Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration Blood, April 15, 2004; 103(8): 3029 - 3037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakajima, T. Gotanda, H. Uchimiya, T. Furukawa, M. Haraguchi, R. Ikeda, T. Sumizawa, H. Yoshida, and S.-i. Akiyama Inhibition of Metastasis of Tumor Cells Overexpressing Thymidine Phosphorylase by 2-Deoxy-L-Ribose Cancer Res., March 1, 2004; 64(5): 1794 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Keane, J. A. Belperio, Y. Y. Xue, M. D. Burdick, and R. M. Strieter Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer J. Immunol., March 1, 2004; 172(5): 2853 - 2860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vitale, A. Schmid-Alliana, V. Breuil, M. Pomeranz, M.-A. Millet, B. Rossi, and H. Schmid-Antomarchi Soluble Fractalkine Prevents Monocyte Chemoattractant Protein-1-Induced Monocyte Migration via Inhibition of Stress-Activated Protein Kinase 2/p38 and Matrix Metalloproteinase Activities J. Immunol., January 1, 2004; 172(1): 585 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strasly, G. Doronzo, P. Capello, D. Valdembri, M. Arese, S. Mitola, P. Moore, G. Alessandri, M. Giovarelli, and F. Bussolino CCL16 activates an angiogenic program in vascular endothelial cells Blood, January 1, 2004; 103(1): 40 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Doubrovina, M. M. Doubrovin, E. Vider, R. B. Sisson, R. J. O'Reilly, B. Dupont, and Y. M. Vyas Evasion from NK Cell Immunity by MHC Class I Chain-Related Molecules Expressing Colon Adenocarcinoma J. Immunol., December 15, 2003; 171(12): 6891 - 6899. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
