| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Infectious Diseases Research Center, Laval University Hospital Center, Sainte-Foy, Quebec, Canada
S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu during inflammatory conditions. Although reports have proposed a proinflammatory role for these proteins, their extracellular activity remains controversial. In this study, we report that S100A8, S100A9, and S100A8/A9 caused neutrophil chemotaxis at concentrations of 10-12–10-9 M. S100A8, S100A9, and S100A8/A9 stimulated shedding of L-selectin, up-regulated and activated Mac-1, and induced neutrophil adhesion to fibrinogen in vitro. Neutralization with Ab showed that this adhesion was mediated by Mac-1. Neutrophil adhesion was also associated with an increase in intracellular calcium levels. However, neutrophil activation by S100A8, S100A9, and S100A8/A9 did not induce actin polymerization. Finally, injection of S100A8, S100A9, or S100A8/A9 into a murine air pouch model led to rapid, transient accumulation of neutrophils confirming their activities in vivo. These studies 1) show that S100A8, S100A9, and S100A8/A9 are potent stimulators of neutrophils and 2) strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites.
This article has been cited by other articles:
|
|
 |
|
  P L E M van Lent, L Grevers, A B Blom, A Sloetjes, J S Mort, T Vogl, W Nacken, W B van den Berg, and J Roth Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis Ann Rheum Dis, December 1, 2008; 67(12): 1750 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bode, A. Luken, C. Kerkhoff, J. Roth, S. Ludwig, and W. Nacken Interaction between S100A8/A9 and Annexin A6 Is Involved in the Calcium-induced Cell Surface Exposition of S100A8/A9 J. Biol. Chem., November 14, 2008; 283(46): 31776 - 31784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sinha, C. Okoro, D. Foell, H. H. Freeze, S. Ostrand-Rosenberg, and G. Srikrishna Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells J. Immunol., October 1, 2008; 181(7): 4666 - 4675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pouliot, I. Plante, M.-A. Raquil, P. A. Tessier, and M. Olivier Myeloid-Related Proteins Rapidly Modulate Macrophage Nitric Oxide Production during Innate Immune Response J. Immunol., September 1, 2008; 181(5): 3595 - 3601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Chung and I. M. Adcock Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Quinton, M. R. Jones, B. E. Robson, B. T. Simms, J. A. Whitsett, and J. P. Mizgerd Alveolar Epithelial STAT3, IL-6 Family Cytokines, and Host Defense during Escherichia coli Pneumonia Am. J. Respir. Cell Mol. Biol., June 1, 2008; 38(6): 699 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Z. Feuerstein Cardiac RAGE in Sepsis: Call TOLL Free for Anti-RAGE Circ. Res., May 23, 2008; 102(10): 1153 - 1154. [Full Text] [PDF]
|
|
|
|
|
|
J. H. Boyd, B. Kan, H. Roberts, Y. Wang, and K. R. Walley S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products Circ. Res., May 23, 2008; 102(10): 1239 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-A. Raquil, N. Anceriz, P. Rouleau, and P. A. Tessier Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia J. Immunol., March 1, 2008; 180(5): 3366 - 3374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakaguchi, H. Sonegawa, H. Murata, M. Kitazoe, J.-i. Futami, K. Kataoka, H. Yamada, and N.-h. Huh S100A11, an Dual Mediator for Growth Regulation of Human Keratinocytes Mol. Biol. Cell, January 1, 2008; 19(1): 78 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. McMorran, S. A. Ouvry Patat, J. B. Carlin, K. Grimwood, A. Jones, D. S. Armstrong, J. C. Galati, P. J. Cooper, C. A. Byrnes, P. W. Francis, et al. Novel Neutrophil-Derived Proteins in Bronchoalveolar Lavage Fluid Indicate an Exaggerated Inflammatory Response in Pediatric Cystic Fibrosis Patients Clin. Chem., October 1, 2007; 53(10): 1782 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stygar, B. Masironi, H. Eriksson, and L. Sahlin Studies on estrogen receptor (ER) {alpha} and {beta} responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists J. Endocrinol., July 1, 2007; 194(1): 101 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Boniface, C. Diveu, F. Morel, N. Pedretti, J. Froger, E. Ravon, M. Garcia, E. Venereau, L. Preisser, E. Guignouard, et al. Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation J. Immunol., April 1, 2007; 178(7): 4615 - 4622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Y. Sroussi, J. Berline, and J. M. Palefsky Oxidation of methionine 63 and 83 regulates the effect of S100A9 on the migration of neutrophils in vitro J. Leukoc. Biol., March 1, 2007; 81(3): 818 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Foell, H. Wittkowski, T. Vogl, and J. Roth S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules J. Leukoc. Biol., January 1, 2007; 81(1): 28 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Greenlee, D. B. Corry, D. A. Engler, R. K. Matsunami, P. Tessier, R. G. Cook, Z. Werb, and F. Kheradmand Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation J. Immunol., November 15, 2006; 177(10): 7312 - 7321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.Y. Sroussi, J. Berline, P. Dazin, P. Green, and J.M. Palefsky S100A8 Triggers Oxidation-sensitive Repulsion of Neutrophils Journal of Dental Research, September 1, 2006; 85(9): 829 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Montgomery, K. Schreck, X. Wang, and S. E. Malawista Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin Infect. Immun., April 1, 2006; 74(4): 2468 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Graham, M. L. Yager, H. D. Hill, K. Byth, G. M. O'Neill, and C. L. Clarke Altered Progesterone Receptor Isoform Expression Remodels Progestin Responsiveness of Breast Cancer Cells Mol. Endocrinol., November 1, 2005; 19(11): 2713 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Srivastava, S. Jung, J. Wilhelm, L. Fink, F. Buhling, T. Welte, R. M. Bohle, W. Seeger, J. Lohmeyer, and U. A. Maus The Inflammatory versus Constitutive Trafficking of Mononuclear Phagocytes into the Alveolar Space of Mice Is Associated with Drastic Changes in Their Gene Expression Profiles J. Immunol., August 1, 2005; 175(3): 1884 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Abe, T. Jibiki, S. Noma, T. Nakajima, H. Saito, and M. Terai Gene Expression Profiling of the Effect of High-Dose Intravenous Ig in Patients with Kawasaki Disease J. Immunol., May 1, 2005; 174(9): 5837 - 5845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Astolfi, L. Landuzzi, G. Nicoletti, C. De Giovanni, S. Croci, A. Palladini, S. Ferrini, M. Iezzi, P. Musiani, F. Cavallo, et al. Gene Expression Analysis of Immune-Mediated Arrest of Tumorigenesis in a Transgenic Mouse Model of HER-2/neu-Positive Basal-Like Mammary Carcinoma Am. J. Pathol., April 1, 2005; 166(4): 1205 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Boniface, F.-X. Bernard, M. Garcia, A. L. Gurney, J.-C. Lecron, and F. Morel IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes J. Immunol., March 15, 2005; 174(6): 3695 - 3702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hsu, R. J. Passey, Y. Endoh, F. Rahimi, P. Youssef, T. Yen, and C. L. Geczy Regulation of S100A8 by Glucocorticoids J. Immunol., February 15, 2005; 174(4): 2318 - 2326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cataisson, A. J. Pearson, S. Torgerson, S. A. Nedospasov, and S. H. Yuspa Protein Kinase C{alpha}-Mediated Chemotaxis of Neutrophils Requires NF-{kappa}B Activity but Is Independent of TNF{alpha} Signaling in Mouse Skin In Vivo J. Immunol., February 1, 2005; 174(3): 1686 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaramillo, M. Godbout, P. H. Naccache, and M. Olivier Signaling Events Involved in Macrophage Chemokine Expression in Response to Monosodium Urate Crystals J. Biol. Chem., December 10, 2004; 279(50): 52797 - 52805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ryckman, C. Gilbert, R. de Medicis, A. Lussier, K. Vandal, and P. A. Tessier Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils J. Leukoc. Biol., August 1, 2004; 76(2): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Sugerman, S. B. Faber, L. M. Willis, A. Petrovic, G. F. Murphy, J. Pappo, D. Silberstein, and M. R. M. van den Brink Kinetics of Gene Expression in Murine Cutaneous Graft-versus-Host Disease Am. J. Pathol., June 1, 2004; 164(6): 2189 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaramillo, I. Plante, N. Ouellet, K. Vandal, P. A. Tessier, and M. Olivier Hemozoin-Inducible Proinflammatory Events In Vivo: Potential Role in Malaria Infection J. Immunol., March 1, 2004; 172(5): 3101 - 3110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Roth, T. Vogl, C. Sunderkotter, and C. Sorg Chemotactic activity of S100A8 and S100A9. J. Immunol., December 1, 2003; 171(11): 5651 - 5651. [Full Text] [PDF]
|
|
|
|
|
|
K. Vandal, P. Rouleau, A. Boivin, C. Ryckman, M. Talbot, and P. A. Tessier Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide J. Immunol., September 1, 2003; 171(5): 2602 - 2609. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
