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The Journal of Immunology, 2003, 170: 2802-2805.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Toll-Like Receptor 9 Expression Is Not Required for CpG DNA-Aided Cross-Presentation of DNA-Conjugated Antigens but Essential for Cross-Priming of CD8 T Cells1

Antje Heit, Tobias Maurer, Hubertus Hochrein, Stefan Bauer, Katharina M. Huster, Dirk H. Busch and Hermann Wagner2

Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany

Covalent linkage of immunostimulatory CpG DNA to OVA results in CpG DNA-aided cross-presentation of OVA by dendritic cells (DCs). In vivo, cross-presentation is conditional for cross-priming of OVA-specific CD8 T cells. In this study, we investigated the involvement of the CpG DNA receptor Toll-like receptor (TLR)9 in CpG DNA-aided cross-presentation and cross-priming. Although CpG DNA-aided cross-presentation is not altered in TLR9-deficient cells, TLR9 is required for maturation of APC allowing cross-priming, as resulting in CTL function. These findings imply that TLR9 does not trigger endocytosis of CpG-OVA conjugates, but activates DCs downstream of endocytosis.


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