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High Expression of Fas Ligand by Synovial Fluid-Derived T Cells in Lyme Arthritis ¹

Karen Roessner^*, Julie Wolfe^*, Cuixia Shi^*, Leonard H. Sigal, Sally Huber and Ralph C. Budd^2,*

Departments of ^* Medicine (Immunobiology) and Pathology, The University of Vermont College of Medicine, Burlington, VT 05405; and Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903

T cells accumulate at epithelial barriers and at sites of inflammation in various infectious and autoimmune diseases, yet little is understood about the function of tissue-infiltrating T cells. We observe that T cells of the V1 subset accumulate in synovial fluid of human Lyme arthritis and are intensely cytolytic toward a wide array of target cells. Particularly striking is that the cytolytic activity is highly prolonged, lasting for at least 3 wk after stimulation of the T cells with Borrelia burgdorferi. Cytolysis is largely Fas dependent and results from very high and prolonged expression of surface Fas ligand, which is transcriptionally regulated. This also manifests in a substantial level of self-induced apoptosis of the T cells. In this capacity, certain T cell subsets may serve as cytolytic sentinels at sites of inflammation, and perhaps at epithelial barriers.

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