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CD7 Is a Differentiation Marker That Identifies Multiple CD8 T Cell Effector Subsets¹

Einar M. Aandahl^2,*, Johan K. Sandberg^*, Karen P. Beckerman^*, Kjetil Taskén, Walter J. Moretto^* and Douglas F. Nixon^*

^* Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141; and Department of Medical Biochemistry, University of Oslo, Oslo, Norway

The adaptive immune response of human CD8 T cells to invading pathogens involves the differentiation of naive cells into memory and effector cells. However, the lineage relationship between memory and effector cells and the differentiation of CD8 T cells into distinct subsets of effector cell subpopulations are subjects of considerable debate. CD7 identifies three populations of CD8 T cells: CD7 high (CD7^high), low (CD7^low), and negative (CD7^neg) that translate into subsets with distinct functional properties. The CD7^high subset contains naive and memory cells and the CD7^low and CD7^neg subsets contain effector cells. The effector cells can functionally be divided into cytokine-secreting effector CD8 T cells and lytic effector CD8 T cells. These data provide a model of human CD8 T cell differentiation in which specialized distinct subpopulations can be identified by expression of CD7.

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