| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Division of Rheumatology/Allergy/Clinical Immunology, University of California, Davis, CA 95616;
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical, Kinashi, Hyogo, Japan;
DNAX Research Institute of Molecular and Biology, Palo Alto, CA 94304;
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; and
¶ First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
Liver dendritic cells (DC) are believed to play important roles in liver immunity, autoimmunity, and in the regulation of hepatic allograft acceptance. However, limited information is available on the phenotypes and functions of DC in the liver. To address this issue, we isolated DC from murine liver using procedures that do not involve collagenase, and characterized the freshly isolated DC population that had not been subjected to in vitro expansion. Thence, based on the expression of CD4, B220, and CD11b, four subsets or groups of hepatic NK1.1-CD11c+ DC were identified with the following phenotypes: B220+CD4+, B220+CD4-, B220-CD11b+, and B220-CD11b-. Each subset was further characterized both phenotypically and functionally. In addition to unique phenotypic expression, each subset displayed different allostimulation capability in mixed lymphocyte reaction assays. All four groups developed DC morphology following in vitro culture with activation agents and synthesized distinct patterns of cytokines in response to different stimuli. Taken together, our results suggest that groups I and II are IFN-
-producing plasmacytoid DC, group III cells are myeloid-related DC, while group IV is a heterogenous population containing both myeloid- and lymphoid-related DC. Our results demonstrate the highly heterogeneous nature of hepatic DC, which is in agreement with the unique requirements for APC in the complex liver environment.
This article has been cited by other articles:
|
|
 |
|
  A W Thomson and P D Robbins Tolerogenic dendritic cells for autoimmune disease and transplantation Ann Rheum Dis, December 1, 2008; 67(Suppl_3): iii90 - iii96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Burt, G. Plitas, J. A. Stableford, H. M. Nguyen, Z. M. Bamboat, V. G. Pillarisetty, and R. P. DeMatteo CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis J. Leukoc. Biol., October 1, 2008; 84(4): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D H Adams, B Eksteen, and S M Curbishley Immunology of the gut and liver: a love/hate relationship Gut, June 1, 2008; 57(6): 838 - 848. [Full Text] [PDF]
|
|
|
|
 |
|
 K.-J. Hong, J. R. Wickstrum, H.-W. Yeh, and M. J. Parmely Toll-Like Receptor 2 Controls the Gamma Interferon Response to Francisella tularensis by Mouse Liver Lymphocytes Infect. Immun., November 1, 2007; 75(11): 5338 - 5345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hokeness-Antonelli, M. J. Crane, A. M. Dragoi, W.-M. Chu, and T. P. Salazar-Mather IFN-{alpha}beta-Mediated Inflammatory Responses and Antiviral Defense in Liver Is TLR9-Independent but MyD88-Dependent during Murine Cytomegalovirus Infection J. Immunol., November 1, 2007; 179(9): 6176 - 6183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Caldwell, J. Tschoep, and A. B. Lentsch Lymphocyte function during hepatic ischemia/reperfusion injury J. Leukoc. Biol., September 1, 2007; 82(3): 457 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, E. Calomeni, J. Wen, K. Ozato, R. Shen, and J.-X. Gao Natural killer dendritic cells are an intermediate of developing dendritic cells J. Leukoc. Biol., June 1, 2007; 81(6): 1422 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tsung, N. Zheng, G. Jeyabalan, K. Izuishi, J. R. Klune, D. A. Geller, M. T. Lotze, L. Lu, and T. R. Billiar Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury J. Leukoc. Biol., January 1, 2007; 81(1): 119 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Yrlid, V. Cerovic, S. Milling, C. D. Jenkins, J. Zhang, P. R. Crocker, L. S. Klavinskis, and G. G. MacPherson Plasmacytoid Dendritic Cells Do Not Migrate in Intestinal or Hepatic Lymph J. Immunol., November 1, 2006; 177(9): 6115 - 6121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Frelin, E D Brenndorfer, G Ahlen, M Weiland, C Hultgren, M Alheim, H Glaumann, B Rozell, D R Milich, J G Bode, et al. The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor {alpha} mediated liver disease Gut, October 1, 2006; 55(10): 1475 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Bleier, S. C. Katz, U. I. Chaudhry, V. G. Pillarisetty, T. P. Kingham III, A. B. Shah, J. R. Raab, and R. P. DeMatteo Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J. Immunol., June 15, 2006; 176(12): 7189 - 7195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. I. Chaudhry, S. C. Katz, T. P. Kingham, V. G. Pillarisetty, J. R. Raab, A. B. Shah, and R. P. DeMatteo In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells FASEB J, May 1, 2006; 20(7): 982 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-X. Yang, Z.-X. Lian, K. Kikuchi, Y. Moritoki, A. A. Ansari, Y.-J. Liu, S. Ikehara, and M. E. Gershwin Plasmacytoid Dendritic Cells of Different Origins Have Distinct Characteristics and Function: Studies of Lymphoid Progenitors versus Myeloid Progenitors J. Immunol., December 1, 2005; 175(11): 7281 - 7287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Omatsu, T. Iyoda, Y. Kimura, A. Maki, M. Ishimori, N. Toyama-Sorimachi, and K. Inaba Development of Murine Plasmacytoid Dendritic Cells Defined by Increased Expression of an Inhibitory NK Receptor, Ly49Q J. Immunol., June 1, 2005; 174(11): 6657 - 6662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-X. Yang, Z.-X. Lian, K. Kikuchi, Y.-J. Liu, A. A. Ansari, S. Ikehara, and M. E. Gershwin CD4- Plasmacytoid Dendritic Cells (pDCs) Migrate in Lymph Nodes by CpG Inoculation and Represent a Potent Functional Subset of pDCs J. Immunol., March 15, 2005; 174(6): 3197 - 3203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12 J. Immunol., March 1, 2005; 174(5): 2612 - 2618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. De Creus, M. Abe, A. H. Lau, H. Hackstein, G. Raimondi, and A. W. Thomson Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin J. Immunol., February 15, 2005; 174(4): 2037 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cataldegirmen, S. Zeng, N. Feirt, N. Ippagunta, H. Dun, W. Qu, Y. Lu, L. L. Rong, M. A. Hofmann, T. Kislinger, et al. RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-{alpha} and NF-{kappa}B J. Exp. Med., February 7, 2005; 201(3): 473 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-X. Lian, K. Kikuchi, G.-X. Yang, A. A. Ansari, S. Ikehara, and M. E. Gershwin Expansion of Bone Marrow IFN-{alpha}-Producing Dendritic Cells in New Zealand Black (NZB) Mice: High Level Expression of TLR9 and Secretion of IFN-{alpha} in NZB Bone Marrow J. Immunol., October 15, 2004; 173(8): 5283 - 5289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Palamara, S. Meindl, M. Holcmann, P. Luhrs, G. Stingl, and M. Sibilia Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod J. Immunol., September 1, 2004; 173(5): 3051 - 3061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. de Heer, H. Hammad, T. Soullie, D. Hijdra, N. Vos, M. A.M. Willart, H. C. Hoogsteden, and B. N. Lambrecht Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen J. Exp. Med., July 6, 2004; 200(1): 89 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Katz, V. G. Pillarisetty, J. I. Bleier, A. B. Shah, and R. P. DeMatteo Liver Sinusoidal Endothelial Cells Are Insufficient to Activate T Cells J. Immunol., July 1, 2004; 173(1): 230 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Suzuki, K. Honma, T. Matsuyama, K. Suzuki, K. Toriyama, I. Akitoyo, K. Yamamoto, T. Suematsu, M. Nakamura, K. Yui, et al. From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8{alpha}- dendritic cell development PNAS, June 15, 2004; 101(24): 8981 - 8986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Homann, D. B. McGavern, and M. B. A. Oldstone Visualizing the Viral Burden: Phenotypic and Functional Alterations of T Cells and APCs during Persistent Infection J. Immunol., May 15, 2004; 172(10): 6239 - 6250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Johansson and M. J. Wick Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter J. Immunol., February 15, 2004; 172(4): 2496 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Pillarisetty, A. B. Shah, G. Miller, J. I. Bleier, and R. P. DeMatteo Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition J. Immunol., January 15, 2004; 172(2): 1009 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, R. J. Rossi, S. J. McSorley, and A. T. Vella T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation J. Immunol., January 1, 2004; 172(1): 248 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A H Lau, A de Creus, L Lu, and A W Thomson Liver tolerance mediated by antigen presenting cells: fact or fiction? Gut, August 1, 2003; 52(8): 1075 - 1078. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
