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CUTTING EDGE |
* Division of Dermatology, Department of Medicine, University of California and Veterans Affairs Medical Center, San Diego, CA 92161;
San Gallicano Dermatological Institute (Istituto di Ricerca e Cura a Carattere Scientifico), Rome, Italy; and
Department of Infectious Diseases, Johnson & Johnson Pharmaceutical Research and Development, San Diego, CA 92121
Cathelicidins (caths) are peptides that are expressed at high levels in neutrophils and some epithelia and can act as natural antibiotics by directly killing a wide range of microorganisms. We hypothesized that caths are expressed in mast cells (MCs), because these cells have been previously associated with inherent antimicrobial activity. Cultured murine MCs contained abundant amounts of cathelin-related antimicrobial peptide (AMP), the murine cath, and this expression was inducible by LPS or lipoteichoic acid. Human skin MCs also expressed cath as detected by immunohistochemical analysis for the human cath LL-37. The functional significance of this expression was shown by comparing MCs cultured from normal mice to MCs from littermates deficient in the cathelin-related AMP gene (Cnlp-). MCs derived from Cnlp-/- animals had a 50% reduction in their ability to kill group A Streptococcus. These MCs expressed equivalent amounts of mRNA for murine 
-defensin-4, a -defensin AMP. Thus, different antimicrobials can be identified in MCs, and the presence of cath is necessary for efficient bacterial killing. These observations suggest that the presence of cath is vital to the ability of mammalian MCs to participate in antimicrobial defense.
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