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The Journal of Immunology, 2003, 170: 2269-2273.
Copyright © 2003 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Histamine Inhibits IFN-{alpha} Release from Plasmacytoid Dendritic Cells

Alessandra Mazzoni*, Cynthia A. Leifer*, Gregory E. D. Mullen*, Margaret N. Kennedy*, Dennis M. Klinman{dagger} and David M. Segal1,*

* Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892; and {dagger} Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892

Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2 in their T cell polarizing function. In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-{alpha} and TNF-{alpha} and a moderate switch in their capacity to polarize naive T cells. Our findings provide an explanation for low levels of type I IFN frequently observed in atopic individuals.


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