| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Servicio de
*
Reumatología y Unidad de Investigación and
Traumatología, Hospital 12 de Octubre, Madrid, Spain; and
Servicio de Reumatología, Hospital Juan Canalejo, Coruña, Spain
CXCL12 (stromal cell-derived factor-1) is a potent CXC chemokine that is constitutively expressed by stromal resident cells. Although it is considered a homeostatic rather than an inflammatory chemokine, CXCL12 has been immunodetected in different inflammatory diseases, but also in normal tissues, ant its potential functions and regulation in inflammation are not well known. In this study, we examined the cellular sources of CXCL12 gene expression and the mechanism and effects of its interactions with endothelial cells in rheumatoid arthritis synovium. We show that CXCL12 mRNA was not overexpressed nor induced in cultured rheumatoid synoviocytes, but it specifically accumulated in the rheumatoid hyperplastic lining layer and endothelium. CXCL12 gene expression was restricted to fibroblast-like synoviocytes, whereas endothelial cells did not express CXCL12 mRNA, but displayed the protein on heparitinase-sensitive factors. CXCL12 colocalized with the angiogenesis marker 
v
3 integrin in rheumatoid endothelium and induced angiogenesis in s.c. Matrigel plugs in mice. The angiogenic activity of rheumatoid synovial fluid in vivo was abrogated by specific immunodepletion of CXCL12. Our results indicate that synoviocyte-derived CXCL12 accumulates and it is immobilized on heparan sulfate molecules of endothelial cells, where it can promote angiogenesis and inflammatory cell infiltration, supporting a multifaceted function for this chemokine in the pathogenesis of rheumatoid arthritis.
This article has been cited by other articles:
|
|
 |
|
  B. J. Pichler, H. F. Wehrl, and M. S. Judenhofer Latest Advances in Molecular Imaging Instrumentation J. Nucl. Med., June 1, 2008; 49(Suppl_2): 5S - 23S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Murooka, R. Rahbar, L. C. Platanias, and E. N. Fish CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1 Blood, May 15, 2008; 111(10): 4892 - 4901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yano, Z. Liu, J. Donovan, M. K. Thomas, and J. F. Habener Stromal Cell Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic {beta}-Cell Survival by Activation of the Prosurvival Kinase Akt Diabetes, December 1, 2007; 56(12): 2946 - 2957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hokanson, R. Fudge, R. Chowdhary, and D. Busbee Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate Human and Experimental Toxicology, September 1, 2007; 26(9): 747 - 752. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Petty, V. Sueblinvong, C. C. Lenox, C. C. Jones, G. P. Cosgrove, C. D. Cool, P. R. Rai, K. K. Brown, D. J. Weiss, M. E. Poynter, et al. Pulmonary Stromal-Derived Factor-1 Expression and Effect on Neutrophil Recruitment during Acute Lung Injury J. Immunol., June 15, 2007; 178(12): 8148 - 8157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D Canete, B. Santiago, T. Cantaert, R. Sanmarti, A. Palacin, R. Celis, E. Graell, B. Gil-Torregrosa, D. Baeten, and J. L Pablos Ectopic lymphoid neogenesis in psoriatic arthritis Ann Rheum Dis, June 1, 2007; 66(6): 720 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. McCandless, Q. Wang, B. M. Woerner, J. M. Harper, and R. S. Klein CXCL12 Limits Inflammation by Localizing Mononuclear Infiltrates to the Perivascular Space during Experimental Autoimmune Encephalomyelitis J. Immunol., December 1, 2006; 177(11): 8053 - 8064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Murooka, M. M. Wong, R. Rahbar, B. Majchrzak-Kita, A. E. I. Proudfoot, and E. N. Fish CCL5-CCR5-mediated Apoptosis in T Cells: REQUIREMENT FOR GLYCOSAMINOGLYCAN BINDING AND CCL5 AGGREGATION J. Biol. Chem., September 1, 2006; 281(35): 25184 - 25194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Gutierrez-Canas, Y. Juarranz, B. Santiago, A. Arranz, C. Martinez, M. Galindo, M. Paya, R. P. Gomariz, and J. L. Pablos VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts Rheumatology, May 1, 2006; 45(5): 527 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sen Wnt signalling in rheumatoid arthritis Rheumatology, June 1, 2005; 44(6): 708 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M van Oosterhout, E W N Levarht, J K Sont, T W J Huizinga, R E M Toes, and J M van Laar Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF{alpha} and IL18 but not CXCL12 Ann Rheum Dis, April 1, 2005; 64(4): 537 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Burman, O. Haworth, D. L. Hardie, E. N. Amft, C. Siewert, D. G. Jackson, M. Salmon, and C. D. Buckley A Chemokine-Dependent Stromal Induction Mechanism for Aberrant Lymphocyte Accumulation and Compromised Lymphatic Return in Rheumatoid Arthritis J. Immunol., February 1, 2005; 174(3): 1693 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Lewis Radiolabeled RGD Peptides Move Beyond Cancer: PET Imaging of Delayed-Type Hypersensitivity Reaction J. Nucl. Med., January 1, 2005; 46(1): 2 - 4. [Full Text] [PDF]
|
|
|
|
|
|
B. J. Pichler, M. Kneilling, R. Haubner, H. Braumuller, M. Schwaiger, M. Rocken, and W. A. Weber Imaging of Delayed-Type Hypersensitivity Reaction by PET and 18F-Galacto-RGD J. Nucl. Med., January 1, 2005; 46(1): 184 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sadir, A. Imberty, F. Baleux, and H. Lortat-Jacob Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV J. Biol. Chem., October 15, 2004; 279(42): 43854 - 43860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J J Haringman, J Ludikhuize, and P P Tak Chemokines in joint disease: the key to inflammation? Ann Rheum Dis, October 1, 2004; 63(10): 1186 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lande, E. Giacomini, B. Serafini, B. Rosicarelli, G. D. Sebastiani, G. Minisola, U. Tarantino, V. Riccieri, G. Valesini, and E. M. Coccia Characterization and Recruitment of Plasmacytoid Dendritic Cells in Synovial Fluid and Tissue of Patients with Chronic Inflammatory Arthritis J. Immunol., August 15, 2004; 173(4): 2815 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Barnes, B. J. Aronow, L. K. Luyrink, M. B. Moroldo, P. Pavlidis, M. H. Passo, A. A. Grom, R. Hirsch, E. H. Giannini, R. A. Colbert, et al. Gene expression in juvenile arthritis and spondyloarthropathy: pro-angiogenic ELR+ chemokine genes relate to course of arthritis Rheumatology, August 1, 2004; 43(8): 973 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Curnow, K. Wloka, J. M. Faint, N. Amft, C. M. G. Cheung, V. Savant, J. Lord, A. N. Akbar, C. D. Buckley, P. I. Murray, et al. Topical Glucocorticoid Therapy Directly Induces Up-Regulation of Functional CXCR4 on Primed T Lymphocytes in the Aqueous Humor of Patients with Uveitis J. Immunol., June 1, 2004; 172(11): 7154 - 7161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. van Buul and P. L. Hordijk Signaling in Leukocyte Transendothelial Migration Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 824 - 833. [Abstract] [Full Text]
|
|
|
|
|
|
M. G. Juarranz, B. Santiago, M. Torroba, I. Gutierrez-Canas, G. Palao, M. Galindo, C. Abad, C. Martinez, J. Leceta, J. L. Pablos, et al. Vasoactive intestinal peptide modulates proinflammatory mediator synthesis in osteoarthritic and rheumatoid synovial cells Rheumatology, April 1, 2004; 43(4): 416 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Salcedo, X. Zhang, H. A. Young, N. Michael, K. Wasserman, W.-H. Ma, M. Martins-Green, W. J. Murphy, and J. J. Oppenheim Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells Blood, September 15, 2003; 102(6): 1966 - 1977. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
