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*Tuberculosis
The Journal of Immunology, 2003, 170: 2046-2052.
Copyright © 2003 by The American Association of Immunologists

Persistence and Turnover of Antigen-Specific CD4 T Cells During Chronic Tuberculosis Infection in the Mouse 1

Gary M. Winslow2,*,{dagger}, Alan D. Roberts{dagger}, Marcia A. Blackman{dagger} and David L. Woodland{dagger}

* Wadsworth Center, New York State Department of Health, Albany, NY 12201; and {dagger} The Trudeau Institute, Saranac Lake, NY 12983

CD4 T cells are critical for resistance to Mycobacterium tuberculosis infection, but how effective T cell responses are maintained during chronic infection is not well understood. To address this question we examined the CD4 T cell response to a peptide from ESAT-6 during tuberculosis infection in the mouse. The ESAT-61–20/IAb-specific CD4 T cell response in the lungs, mediastinal lymph nodes, and spleen reached maxima 3–4 wk postinfection, when the bacteria came under the control of the immune response. Once chronic infection was established, the relative frequencies of Ag-specific CD4 T cells were maintained at nearly constant levels for at least 160 days. ESAT-61–20/IAb-specific CD4 T cells that responded in vitro expressed activation markers characteristic of chronically activated effector cells and used a limited V{beta} repertoire that was clonally stable in vivo for at least 12 wk. 5-Bromo-2-deoxyuridine incorporation studies indicated a relatively high rate of cell division among both total CD4 and ESAT-61–20/IAb-specific CD4 T cells during acute infection, but the degree of 5-bromo-2-deoxyuridine incorporation by both the CD4 T cells and the Ag-specific cells declined at least 3-fold during chronic infection. The data indicate that the peripheral ESAT-61–20/IAb-specific CD4 T cell response to M. tuberculosis is characterized during the acute phase of infection by a period of extensive proliferation, but once bacterial control is achieved, this is followed during chronic infection by an extended containment phase that is associated with a persistent response of activated, yet more slowly proliferating, T cells.




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