| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Upon Triggering of Activating Ly49D NK Receptors In Vitro and In Vivo: Costimulation with IL-12 or IL-18 Overrides Inhibitory Receptors 1
Laboratory of Experimental Immunology, National Cancer Institute-Center for Cancer Research, Frederick, MD 21702
NK cells can express both activating and inhibitory Ly49 receptors on their cell surface. When cells expressing both receptors are presented with a ligand, inhibition dominates the functional outcome. In this report we demonstrate that costimulation of the activating Ly49D murine NK cell receptor with IL-12 or IL-18 is capable of over-riding the inhibitory Ly49G2 receptor blockade for cytokine production both in vitro and in vivo. This synergy is mediated by and dependent upon Ly49D-expressing NK cells and results in significant systemic expression of IFN-
. This would place NK cells and their activating Ly-49 receptors as important initiators of microbial, antiviral, and antitumor immunity and provide a mechanism for the release of activating Ly49 receptors from inhibitory receptor blockade.
This article has been cited by other articles:
|
|
 |
|
  S. J. Park, M. A. Hughes, M. Burdick, R. M. Strieter, and B. Mehrad Early NK Cell-Derived IFN-{gamma} Is Essential to Host Defense in Neutropenic Invasive Aspergillosis J. Immunol., April 1, 2009; 182(7): 4306 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nandakumar, S. N. Woolard, D. Yuan, B. T. Rouse, and U. Kumaraguru Natural Killer Cells as Novel Helpers in Anti-Herpes Simplex Virus Immune Response J. Virol., November 1, 2008; 82(21): 10820 - 10831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Winkler-Pickett, H. A. Young, J. M. Cherry, J. Diehl, J. Wine, T. Back, W. E. Bere, A. T. Mason, and J. R. Ortaldo In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses J. Immunol., April 1, 2008; 180(7): 4495 - 4506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Shahjahan Miah, T. L. Hughes, and K. S. Campbell KIR2DL4 Differentially Signals Downstream Functions in Human NK Cells through Distinct Structural Modules J. Immunol., March 1, 2008; 180(5): 2922 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lundqvist, J. Philip McCoy, L. Samsel, and R. Childs Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors Blood, April 15, 2007; 109(8): 3603 - 3606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Osman, D. N. Burshtyn, and K. P. Kane Activating Ly-49 Receptors Regulate LFA-1-Mediated Adhesion by NK Cells J. Immunol., February 1, 2007; 178(3): 1261 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuchiyama, Y. Nakamoto, Y. Sakai, Y. Marukawa, M. Kitahara, N. Mukaida, and S. Kaneko Prolonged, NK Cell-Mediated Antitumor Effects of Suicide Gene Therapy Combined with Monocyte Chemoattractant Protein-1 against Hepatocellular Carcinoma J. Immunol., January 1, 2007; 178(1): 574 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Ortaldo, R. Winkler-Pickett, J. Wigginton, M. Horner, E. W. Bere, A. T. Mason, N. Bhat, J. Cherry, M. Sanford, D. L. Hodge, et al. Regulation of ITAM-positive receptors: role of IL-12 and IL-18 Blood, February 15, 2006; 107(4): 1468 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Atochina and D. Harn LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction Clin. Vaccine Immunol., September 1, 2005; 12(9): 1041 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Osman, E. T. Silver, J. C. Varghese, C. S. Chang, D.-E. Gong, G. F. Audette, B. Hazes, and K. P. Kane Epitope mapping of Ly-49G and G-like receptors: CK-1 antibody defines a polymorphic site of functional interaction with class I ligand J. Leukoc. Biol., May 1, 2005; 77(5): 644 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection Infect. Immun., March 1, 2005; 73(3): 1890 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Gumperz CD1d-restricted "NKT" cells and myeloid IL-12 production: an immunological crossroads leading to promotion or suppression of effective anti-tumor immune responses? J. Leukoc. Biol., August 1, 2004; 76(2): 307 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inngjerdingen, B. Rolstad, and J. C. Ryan Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12 J. Immunol., September 15, 2003; 171(6): 2889 - 2895. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
