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The Journal of Immunology, 2003, 170: 1354-1361.
Copyright © 2003 by The American Association of Immunologists

Block in Development at the Pre-B-II to Immature B Cell Stage in Mice Without Ig{kappa} and Ig{lambda} Light Chain 1

Xiangang Zou, Tony A. Piper, Jennifer A. Smith, Nicholas D. Allen, Jian Xian and Marianne Brüggemann2

Laboratory of Developmental Immunology, The Babraham Institute, Babraham, Cambridge, United Kingdom

Silencing individual C (constant region) {lambda} genes in a {kappa}-/- background reduces mature B cell levels, and L chain-deficient ({lambda}-/-{kappa}-/-) mice attain a complete block in B cell development at the stage when L chain rearrangement, resulting in surface IgM expression, should be completed. L chain deficiency prevents B cell receptor association, and L chain function cannot be substituted (e.g., by surrogate L chain). Nevertheless, precursor cell levels, controlled by developmental progression and checkpoint apoptosis, are maintained, and B cell development in the bone marrow is fully retained up to the immature stage. L chain deficiency allows H chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal.




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