| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Immunology, Infection and Inflammation, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
Cell locomotion is crucial to the induction of an effective immune response. We report here the chemoattraction of CD4+ T cells by IL-18, a member of the IL-1 cytokine family. Recombinant IL-18 increased the proportion of T cells in polarized morphology in vitro and stimulated their subsequent invasion into collagen gels in an IL-18 concentration gradient-dependent manner. Immunofluorescent microscopy studies determined that the major cell type responding to IL-18 was IL-18R+CD4+. Importantly, synovial CD4+ T cells from patients with rheumatoid arthritis responded to IL-18, adopting polarized morphology and gel invasion without further activation ex vivo, indicating the physiologic relevance of our observations. Finally, injection of rIL-18 into the footpad of DBA/1 mice led to local accumulation of inflammatory cells. These data therefore demonstrate for the first time lymphocyte chemoattractant properties of a member of the IL-1 cytokine family and its relevance in inflammatory diseases.
This article has been cited by other articles:
|
|
 |
|
  Y. Wang, G. Chaudhri, R. J. Jackson, and G. Karupiah IL-12p40 and IL-18 Play Pivotal Roles in Orchestrating the Cell-Mediated Immune Response to a Poxvirus Infection J. Immunol., September 1, 2009; 183(5): 3324 - 3331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lochner, K. Kastenmuller, M. Neuenhahn, H. Weighardt, D. H. Busch, W. Reindl, and I. Forster Decreased Susceptibility of Mice to Infection with Listeria monocytogenes in the Absence of Interleukin-18 Infect. Immun., September 1, 2008; 76(9): 3881 - 3890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sakai, Y. Sugawara, T. Kuroishi, T. Sasano, and S. Sugawara Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjogren's Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18 J. Immunol., August 15, 2008; 181(4): 2898 - 2906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-M. Dai, Z.-Z. Shan, H. Xu, and K. Nishioka Cellular targets of interleukin-18 in rheumatoid arthritis Ann Rheum Dis, November 1, 2007; 66(11): 1411 - 1418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Bruun, B. Stallknecht, J. W Helge, and B. Richelsen Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss Eur. J. Endocrinol., October 1, 2007; 157(4): 465 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Orozco, E. Gemmell, M. Bickel, and G.J. Seymour Interleukin 18 and Periodontal Disease Journal of Dental Research, July 1, 2007; 86(7): 586 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Wolf, G. Li, A. Varadhachary, K. Petrak, M. Schneyer, D. Li, J. Ongkasuwan, X. Zhang, R. J. Taylor, S. E. Strome, et al. Oral Lactoferrin Results in T Cell-Dependent Tumor Inhibition of Head and Neck Squamous Cell Carcinoma In vivo Clin. Cancer Res., March 1, 2007; 13(5): 1601 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, R. Yadav, R. J. Rossi, C. E. Ruby, A. D. Weinberg, H. L. Aguila, and A. T. Vella IL-18 Bridges Innate and Adaptive Immunity through IFN-{gamma} and the CD134 Pathway J. Immunol., July 1, 2006; 177(1): 234 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Skurk, H. Kolb, S. Muller-Scholze, K. Rohrig, H. Hauner, and C. Herder The proatherogenic cytokine interleukin-18 is secreted by human adipocytes Eur. J. Endocrinol., June 1, 2005; 152(6): 863 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wyburn, H. Wu, J. Yin, M. Jose, J. Eris, and S. Chadban Macrophage-derived interleukin-18 in experimental renal allograft rejection Nephrol. Dial. Transplant., April 1, 2005; 20(4): 699 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Zabel, A. M. Silverio, and E. C. Butcher Chemokine-Like Receptor 1 Expression and Chemerin-Directed Chemotaxis Distinguish Plasmacytoid from Myeloid Dendritic Cells in Human Blood J. Immunol., January 1, 2005; 174(1): 244 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A.B. Joosten, R. L. Smeets, M. I. Koenders, L. A.M. van den Bersselaar, M. M.A. Helsen, B. Oppers-Walgreen, E. Lubberts, Y. Iwakura, F. A.J. van de Loo, and W. B. van den Berg Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction Am. J. Pathol., September 1, 2004; 165(3): 959 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kaser, S. Kaser, N. C. Kaneider, B. Enrich, C. J. Wiedermann, and H. Tilg Interleukin-18 attracts plasmacytoid dendritic cells (DC2s) and promotes Th1 induction by DC2s through IL-18 receptor expression Blood, January 15, 2004; 103(2): 648 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gutzmer, K. Langer, S. Mommert, M. Wittmann, A. Kapp, and T. Werfel Human Dendritic Cells Express the IL-18R and Are Chemoattracted to IL-18 J. Immunol., December 15, 2003; 171(12): 6363 - 6371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Szmitko, C.-H. Wang, R. D. Weisel, J. R. de Almeida, T. J. Anderson, and S. Verma New Markers of Inflammation and Endothelial Cell Activation: Part I Circulation, October 21, 2003; 108(16): 1917 - 1923. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
