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The Journal of Immunology, 2003, 170: 6183-6189.
Copyright © 2003 by The American Association of Immunologists

Regulatory T Cells Secreting IL-10 Dominate the Immune Response to EBV Latent Membrane Protein 11

Neil A. Marshall, Mark A. Vickers and Robert N. Barker2

Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom

Viruses exploit a number of strategies to evade immune recognition. In this study, we describe a novel mechanism by which EBV, rather than avoiding detection, subverts the immune response by stimulating regulatory T cells that secrete IL-10. Human PBMC from all EBV-seropositive, but not -seronegative, donors responded to both purified latent membrane protein 1 and the corresponding immunodominant peptides with high levels of IL-10 secretion by CD4+ T cells. These IL-10 responses, characteristic of T regulatory 1 cells, inhibited T cell proliferation and IFN-{gamma} secretion induced by both mitogen and recall Ag. It was confirmed that the inhibition was IL-10 dependent by the use of neutralizing Ab. The deviation of the immune response toward suppression is likely to be important in maintaining latency and EBV-associated tumors.




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