The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zeyda, M.
Right arrow Articles by Stulnig, T. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zeyda, M.
Right arrow Articles by Stulnig, T. M.
The Journal of Immunology, 2003, 170: 6033-6039.
Copyright © 2003 by The American Association of Immunologists

Suppression of T Cell Signaling by Polyunsaturated Fatty Acids: Selectivity in Inhibition of Mitogen-Activated Protein Kinase and Nuclear Factor Activation1

Maximilian Zeyda*, Andreas B. Szekeres{dagger}, Marcus D. Säemann{dagger}, René Geyeregger*, Hannes Stockinger{dagger}, Gerhard J. Zlabinger{dagger}, Werner Waldhäusl*,{ddagger} and Thomas M. Stulnig2,*,{ddagger}

* Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism and {dagger} Institute of Immunology, University of Vienna Medical School, Vienna, Austria; and {ddagger} CeMM–Center of Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

Polyunsaturated fatty acids (PUFAs) are known to suppress inflammatory and autoimmune responses and, therefore, clinical applications of PUFAs as immunomodulatory substances are extensively studied. PUFAs are known to inhibit T cell responses, but with respect to TCR/CD3-mediated signal transduction only a block in CD3-induced phospholipase C{gamma}1/calcium signaling has been shown so far. In this study, we investigated PUFA-mediated changes in downstream T cell signal transduction. We show that among the mitogen-activated protein kinase families activation of c-Jun NH2-terminal kinase, but not phosphorylation of extracellular signal-regulated kinase-1/-2 or p38 is inhibited. CD3/CD28-induced activity of NF-AT was markedly reduced by PUFA treatment, while activation of other nuclear receptors (AP-1 and NF-{kappa}B) remained unaltered. Furthermore, IL-2 promoter activity, IL-2 and IL-13 mRNA levels, IL-2 secretion, and IL-2R {alpha}-chain expression were significantly diminished by PUFA treatment, whereas the expression of IFN-{gamma}, IL-4, IL-10, and CD69 remained essentially unaffected by PUFAs. In conclusion, PUFA treatment of T cells inhibits selectively c-Jun NH2-terminal kinase and NF-AT activation, resulting in diminished production of IL-2 and IL-13.




This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
R. Gorjao, S. M. Hirabara, T. M. de Lima, M. F. Cury-Boaventura, and R. Curi
Regulation of interleukin-2 signaling by fatty acids in human lymphocytes
J. Lipid Res., September 1, 2007; 48(9): 2009 - 2019.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. C. Calder and P. Yaqoob
Lipid Rafts--Composition, Characterization, and Controversies
J. Nutr., March 1, 2007; 137(3): 545 - 547.
[Full Text] [PDF]

Home page
 IOVSHome page
W. Chen, D. B. Jump, W. J. Esselman, and J. V. Busik
Inhibition of Cytokine Signaling in Human Retinal Endothelial Cells through Modification of Caveolae/Lipid Rafts by Docosahexaenoic Acid
Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 18 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. R. Shaikh and M. Edidin
Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules
J. Lipid Res., January 1, 2007; 48(1): 127 - 138.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. R. Shaikh and M. Edidin
Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation
Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1277 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. Zhang, W. Kim, L. Zhou, N. Wang, L. H. Ly, D. N. McMurray, and R. S. Chapkin
Dietary Fish Oil Inhibits Antigen-Specific Murine Th1 Cell Development by Suppression of Clonal Expansion
J. Nutr., September 1, 2006; 136(9): 2391 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. E. Loscher, E. Draper, O. Leavy, D. Kelleher, K. H. G. Mills, and H. M. Roche
Conjugated Linoleic Acid Suppresses NF-{kappa}B Activation and IL-12 Production in Dendritic Cells through ERK-Mediated IL-10 Induction
J. Immunol., October 15, 2005; 175(8): 4990 - 4998.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. Zhang, R. Smith, R. S. Chapkin, and D. N. McMurray
Dietary (n-3) Polyunsaturated Fatty Acids Modulate Murine Th1/Th2 Balance toward the Th2 Pole by Suppression of Th1 Development
J. Nutr., July 1, 2005; 135(7): 1745 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. Geyeregger, M. Zeyda, G. J. Zlabinger, W. Waldhausl, and T. M. Stulnig
Polyunsaturated fatty acids interfere with formation of the immunological synapse
J. Leukoc. Biol., May 1, 2005; 77(5): 680 - 688.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Zeyda, M. D. Saemann, K. M. Stuhlmeier, D. G. Mascher, P. N. Nowotny, G. J. Zlabinger, W. Waldhausl, and T. M. Stulnig
Polyunsaturated Fatty Acids Block Dendritic Cell Activation and Function Independently of NF-{kappa}B Activation
J. Biol. Chem., April 8, 2005; 280(14): 14293 - 14301.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.