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The Journal of Immunology, 2003, 170: 5583-5589.
Copyright © 2003 by The American Association of Immunologists

Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors1

Ole E. Sørensen2,*,{dagger}, Jack B. Cowland*, Kim Theilgaard-Mönch*, Lide Liu{dagger}, Tomas Ganz{dagger} and Niels Borregaard*

* Granulocyte Research Laboratory, Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; and {dagger} Host Defense Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when the physical barrier protecting against microbial infections is re-established. We found that the growth factors important in wound healing, insulin-like growth factor I and TGF-{alpha}, induce the expression of the antimicrobial peptides/polypeptides human cationic antimicrobial protein hCAP-18/LL-37, human {beta}-defensin 3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor in human keratinocytes. Both an individual and a synergistic effect of these growth factors were observed. These findings offer an explanation for the expression of these peptides/polypeptides in the skin disease psoriasis and in wound healing and define a host defense role for growth factors in wound healing.




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