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CUTTING EDGE |
* Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Departments of
Ophthalmology and
Parasitology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;
PRESTO, Japan Science and Technology Corporation, Kawaguchi, Saitama, Japan; and
¶
Ontario Cancer Institute and Departments of MedicalBiophysics and Immunology, University of Toronto, Toronto, Ontario, Canada
WSX-1 is a member of the class I cytokine receptor family with homology to IL-12R
2 and is essential for the initial mounting of Th1 responses. STAT1 interacts with tyrosine-phosphorylated WSX-1, and the conserved tyrosine residue of the cytoplasmic domain of WSX-1 is essential for transcriptional activation of STAT1. IL-27 stimulation induced STAT1 phosphorylation in wild-type but not in WSX-1-deficient naive CD4+ T cells. Although IL-27 did not directly induce IFN-
production by wild-type CD4+ T cells, IL-12-dependent IFN- production was augmented by IL-27 stimulation in wild-type naive CD4+ T cells but was impaired in WSX-1-deficient naive CD4+ T cells. Additionally, IL-27 stimulation induced T-bet and IL-12R2 expression in wild-type, but not in WSX-1-deficient, CD4+ T cells. Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system.
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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|
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|
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|
|
|
|
 |
|
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|
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|
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 |
|
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|
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|
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|
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|
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|
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|
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|
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D. Artis, A. Villarino, M. Silverman, W. He, E. M. Thornton, S. Mu, S. Summer, T. M. Covey, E. Huang, H. Yoshida, et al. The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity J. Immunol., November 1, 2004; 173(9): 5626 - 5634. [Abstract] [Full Text] [PDF]
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 A. Morinobu, Y. Kanno, and J. J. O'Shea Discrete Roles for Histone Acetylation in Human T Helper 1 Cell-specific Gene Expression J. Biol. Chem., September 24, 2004; 279(39): 40640 - 40646. [Abstract] [Full Text] [PDF]
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S. Kamiya, T. Owaki, N. Morishima, F. Fukai, J. Mizuguchi, and T. Yoshimoto An Indispensable Role for STAT1 in IL-27-Induced T-bet Expression but Not Proliferation of Naive CD4+ T Cells J. Immunol., September 15, 2004; 173(6): 3871 - 3877. [Abstract] [Full Text] [PDF]
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T. Yoshimoto, K. Okada, N. Morishima, S. Kamiya, T. Owaki, M. Asakawa, Y. Iwakura, F. Fukai, and J. Mizuguchi Induction of IgG2a Class Switching in B Cells by IL-27 J. Immunol., August 15, 2004; 173(4): 2479 - 2485. [Abstract] [Full Text] [PDF]
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A. V. Villarino, E. Huang, and C. A. Hunter Understanding the Pro- and Anti-Inflammatory Properties of IL-27 J. Immunol., July 15, 2004; 173(2): 715 - 720. [Abstract] [Full Text] [PDF]
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R. Goldberg, G. Wildbaum, Y. Zohar, G. Maor, and N. Karin Suppression of Ongoing Adjuvant-Induced Arthritis by Neutralizing the Function of the p28 Subunit of IL-27 J. Immunol., July 15, 2004; 173(2): 1171 - 1178. [Abstract] [Full Text] [PDF]
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A. J. Bancroft, N. E. Humphreys, J. J. Worthington, H. Yoshida, and R. K. Grencis WSX-1: A Key Role in Induction of Chronic Intestinal Nematode Infection J. Immunol., June 15, 2004; 172(12): 7635 - 7641. [Abstract] [Full Text] [PDF]
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K. A. Papadakis, J. L. Prehn, C. Landers, Q. Han, X. Luo, S. C. Cha, P. Wei, and S. R. Targan TL1A Synergizes with IL-12 and IL-18 to Enhance IFN-{gamma} Production in Human T Cells and NK Cells J. Immunol., June 1, 2004; 172(11): 7002 - 7007. [Abstract] [Full Text] [PDF]
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D. Artis, L. M. Johnson, K. Joyce, C. Saris, A. Villarino, C. A. Hunter, and P. Scott Cutting Edge: Early IL-4 Production Governs the Requirement for IL-27-WSX-1 Signaling in the Development of Protective Th1 Cytokine Responses following Leishmania major Infection J. Immunol., April 15, 2004; 172(8): 4672 - 4675. [Abstract] [Full Text] [PDF]
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A. Yamanaka, S. Hamano, Y. Miyazaki, K. Ishii, A. Takeda, T. W. Mak, K. Himeno, A. Yoshimura, and H. Yoshida Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis J. Immunol., March 15, 2004; 172(6): 3590 - 3596. [Abstract] [Full Text] [PDF]
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L. C. Gavrilescu, B. A. Butcher, L. Del Rio, G. A. Taylor, and E. Y. Denkers STAT1 Is Essential for Antimicrobial Effector Function but Dispensable for Gamma Interferon Production during Toxoplasma gondii Infection Infect. Immun., March 1, 2004; 72(3): 1257 - 1264. [Abstract] [Full Text] [PDF]
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S. Pflanz, L. Hibbert, J. Mattson, R. Rosales, E. Vaisberg, J. F. Bazan, J. H. Phillips, T. K. McClanahan, R. de Waal Malefyt, and R. A. Kastelein WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 J. Immunol., February 15, 2004; 172(4): 2225 - 2231. [Abstract] [Full Text] [PDF]
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M. Hisada, S. Kamiya, K. Fujita, M. L. Belladonna, T. Aoki, Y. Koyanagi, J. Mizuguchi, and T. Yoshimoto Potent Antitumor Activity of Interleukin-27 Cancer Res., February 1, 2004; 64(3): 1152 - 1156. [Abstract] [Full Text] [PDF]
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S. Lucas, N. Ghilardi, J. Li, and F. J. de Sauvage IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms PNAS, December 9, 2003; 100(25): 15047 - 15052. [Abstract] [Full Text] [PDF]
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M. Mohty, A. Vialle-Castellano, J. A. Nunes, D. Isnardon, D. Olive, and B. Gaugler IFN-{alpha} Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities J. Immunol., October 1, 2003; 171(7): 3385 - 3393. [Abstract] [Full Text] [PDF]
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