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Autoimmune Encephalomyelitis and Uveitis Induced by T Cell Immunity to Self -Synuclein¹

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

-synuclein is a neuronal protein that accumulates in the plaques that characterize neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. It has been proposed that immunization to peptides of plaque-forming proteins might be used therapeutically to help dissociate pathogenic plaques in the brain. We now report that immunization of Lewis rats with a peptide from -synuclein resulted in acute paralytic encephalomyelitis and uveitis. T cell lines and clones reactive to the peptide adoptively transferred the disease to naive rats. Immunoblotting revealed the presence of -synuclein in heavy myelin, indicating that the expression of -synuclein is not confined to neurons. These results add -synuclein to the roster of encephalitogenic self Ags, point out the potential danger of therapeutic autoimmunization to -synuclein, and alert us to the unsuspected possibility that autoimmunity to -synuclein might play an inflammatory role in the pathogenesis of neurodegeneration.

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The JI 2003 170: 3-4. [Full Text]  

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