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The Journal of Immunology, 2003, 170: 394-399.
Copyright © 2003 by The American Association of Immunologists

CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice1

Damo Xu2,*, Haiying Liu*, Mousa Komai-Koma*, Carol Campbell*, Charlie McSharry*, James Alexander and Foo Y. Liew2,*

* Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom; and Department of Immunology, University of Strathclyde, Glasgow, Glasgow, Scotland, United Kingdom

Regulatory T cells play a major role in modulating the immune response. However, most information on these cells centers on autoimmunity, and there is also considerable controversy on the functional characteristics of these cells. Here we provide direct in vitro and in vivo evidence that CD4+CD25+ regulatory T cells inhibit the differentiation and functions of both Th1 and Th2 cells. Importantly, CD4+CD25+ T cells suppressed the disease development of Leishmania major infection in SCID mice reconstituted with naive CD4+CD25- T cells. Furthermore, CD4+CD25+ T cells inhibited the development of colitis induced by both Th1 and Th2 cells in SCID mice. Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo.




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