| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Laboratory for Experimental Immunology and
Department of Hematology, Academic Medical Center,
Department of Clinical Viro-Immunology, Sanquin Research at CLB, University of Amsterdam,
Division of Cellular Biochemistry, Netherlands Cancer Institute, and
¶ Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands; and
|| Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
The interaction between TNFR family member CD27 and its ligand CD70 promotes lymphocyte expansion and effector cell formation. In humans, control of CD27 function is partly regulated by the restricted expression of CD70. We used newly developed mAbs to characterize murine (m) CD70 expression in vitro and in vivo. On resting lymphocytes and immature dendritic cells (DC), mCD70 is absent. In vitro, Ag receptor triggering induced mCD70 mRNA in T cells, but cell surface protein expression was very low. Activated B cells synthesized much higher levels of mCD70 mRNA than activated T cells and clearly expressed mCD70 at the cell surface. mCD70 cell surface expression could also be induced on the DC line D1 and on in vitro-generated murine DC upon maturation. In lymphoid organs of naive mice, virtually no mCD70-expressing cells were found, with exception of cells in the thymic medulla, which may be epithelial in origin. However, after intranasal infection with influenza virus, lung-infiltrating T cells and T and B cells in draining lymph nodes expressed mCD70 according to immunohistology. In such activated lymphocytes, mCD70 protein is largely retained intracellularly. Plasma membrane expression of mCD70 was only detectable by flow cytometry on a small proportion of lung-infiltrating T cells and peaked at the height of the primary response. Thus, expression of CD70 in the mouse is highly regulated at the transcriptional and posttranslational level. This most likely serves to limit excessive effector cell formation after antigenic stimulation.
This article has been cited by other articles:
|
|
 |
|
  Y. Xiao, V. Peperzak, A. M. Keller, and J. Borst CD27 Instructs CD4+ T Cells to Provide Help for the Memory CD8+ T Cell Response after Protein Immunization J. Immunol., July 15, 2008; 181(2): 1071 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Dolfi, A. C. Boesteanu, C. Petrovas, D. Xia, E. A. Butz, and P. D. Katsikis Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells J. Immunol., March 1, 2008; 180(5): 2912 - 2921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Turnquist, G. Raimondi, A. F. Zahorchak, R. T. Fischer, Z. Wang, and A. W. Thomson Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance J. Immunol., June 1, 2007; 178(11): 7018 - 7031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. French, V. Y. Taraban, G. R. Crowther, T. F. Rowley, J. C. Gray, P. W. Johnson, A. L. Tutt, A. Al-Shamkhani, and M. J. Glennie Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation Blood, June 1, 2007; 109(11): 4810 - 4815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Keller, T. A. Groothuis, E. A. M. Veraar, M. Marsman, L. M. de Buy Wenniger, H. Janssen, J. Neefjes, and J. Borst Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules PNAS, April 3, 2007; 104(14): 5989 - 5994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Sanchez, J. A. McWilliams, C. Haluszczak, H. Yagita, and R. M. Kedl Combined TLR/CD40 Stimulation Mediates Potent Cellular Immunity by Regulating Dendritic Cell Expression of CD70 In Vivo J. Immunol., February 1, 2007; 178(3): 1564 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Kapina, G. S. Shepelkova, V. V. Mischenko, P. Sayles, P. Bogacheva, G. Winslow, A. S. Apt, and I. V. Lyadova CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-{gamma}, and Protect the Host against Tuberculosis Infection J. Immunol., January 15, 2007; 178(2): 976 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Wieland, M. E. Kerver, S. Florquin, M. A. Nolte, J. Borst, R. van Lier, M. H. J. van Oers, and T. van der Poll CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome Int. Immunol., November 1, 2006; 18(11): 1531 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Huang, K. W. Kerstann, M. Ahmadzadeh, Y. F. Li, M. El-Gamil, S. A. Rosenberg, and P. F. Robbins Modulation by IL-2 of CD70 and CD27 Expression on CD8+ T Cells: Importance for the Therapeutic Effectiveness of Cell Transfer Immunotherapy. J. Immunol., June 15, 2006; 176(12): 7726 - 7735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Soroosh, S. Ine, K. Sugamura, and N. Ishii OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity J. Immunol., May 15, 2006; 176(10): 5975 - 5987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Law, K. A. Gordon, B. E. Toki, A. K. Yamane, M. A. Hering, C. G. Cerveny, J. M. Petroziello, M. C. Ryan, L. Smith, R. Simon, et al. Lymphocyte Activation Antigen CD70 Expressed by Renal Cell Carcinoma Is a Potential Therapeutic Target for Anti-CD70 Antibody-Drug Conjugates Cancer Res., February 15, 2006; 66(4): 2328 - 2337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Israel, M. Gulley, S. Elmore, S. Ferrini, W.-h. Feng, and S. C. Kenney Anti-CD70 antibodies: a potential treatment for EBV+ CD70-expressing lymphomas Mol. Cancer Ther., December 1, 2005; 4(12): 2037 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. de Bree, E. M.M. van Leeuwen, T. A. Out, H. M. Jansen, R. E. Jonkers, and R. A.W. van Lier Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung J. Exp. Med., November 21, 2005; 202(10): 1433 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hendriks, Y. Xiao, J. W. A. Rossen, K. F. van der Sluijs, K. Sugamura, N. Ishii, and J. Borst During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion J. Immunol., August 1, 2005; 175(3): 1665 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. J. Bullock and H. Yagita Induction of CD70 on Dendritic Cells through CD40 or TLR Stimulation Contributes to the Development of CD8+ T Cell Responses in the Absence of CD4+ T Cells J. Immunol., January 15, 2005; 174(2): 710 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Ochsenbein, S. R. Riddell, M. Brown, L. Corey, G. M. Baerlocher, P. M. Lansdorp, and P. D. Greenberg CD27 Expression Promotes Long-Term Survival of Functional Effector-Memory CD8+ Cytotoxic T Lymphocytes in HIV-infected Patients J. Exp. Med., December 6, 2004; 200(11): 1407 - 1417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Taraban, T. F. Rowley, and A. Al-Shamkhani Cutting Edge: A Critical Role for CD70 in CD8 T Cell Priming by CD40-Licensed APCs J. Immunol., December 1, 2004; 173(11): 6542 - 6546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Arens, M. A. Nolte, K. Tesselaar, B. Heemskerk, K. A. Reedquist, R. A. W. van Lier, and M. H. J. van Oers Signaling through CD70 Regulates B Cell Activation and IgG Production J. Immunol., September 15, 2004; 173(6): 3901 - 3908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. van Doorn, R. Dijkman, M. H. Vermeer, J. J. Out-Luiting, E. M. H. van der Raaij-Helmer, R. Willemze, and C. P. Tensen Aberrant Expression of the Tyrosine Kinase Receptor EphA4 and the Transcription Factor Twist in Sezary Syndrome Identified by Gene Expression Analysis Cancer Res., August 15, 2004; 64(16): 5578 - 5586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Garcia, A. B. de Heredia, T. Bellon, E. Carpio, M. Llano, E. Caparros, P. Aparicio, and M. Lopez-Botet Signalling via CD70, a member of the TNF family, regulates T cell functions J. Leukoc. Biol., July 1, 2004; 76(1): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xiao, J. Hendriks, P. Langerak, H. Jacobs, and J. Borst CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation J. Immunol., June 15, 2004; 172(12): 7432 - 7441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Arens, K. Schepers, M. A. Nolte, M. F. van Oosterwijk, R. A.W. van Lier, T. N.M. Schumacher, and M. H.J. van Oers Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell Formation J. Exp. Med., June 7, 2004; 199(11): 1595 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Rowley and A. Al-Shamkhani Stimulation by Soluble CD70 Promotes Strong Primary and Secondary CD8+ Cytotoxic T Cell Responses In Vivo J. Immunol., May 15, 2004; 172(10): 6039 - 6046. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
