| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852
The 
2 integrin LFA-1 (CD11a/CD18) mediates adhesion
of lymphocytes to cells expressing ICAM. The strength of this adhesion
is regulated by different signals delivered by cytokines and
chemokines, and by the TCR in the case of T cells. To determine the
receptor-ligand interactions required for adhesion of resting NK cells,
Drosophila cells expressing different combinations of
ligands of human NK cell receptors were generated. Expression of
ICAM-1 alone was sufficient for an adhesion of resting NK cells that
was sensitive to inhibitors of src family kinase and of
phosphatidylinositol 3-kinase. Binding of resting NK cells to
solid-phase ICAM-1 showed similar signaling requirements. A pulse of
either IL-2 or IL-15 to resting NK cells resulted in strongly enhanced,
actin-dependent adhesion to insect cells expressing ICAM-1 alone.
Coexpression of either LFA-3 (CD58) or CD48 with ICAM-1 resulted in
strong adhesion by resting NK cells, even in the absence of cytokines.
Therefore, receptors for LFA-3 and CD48 on resting NK cells strengthen
the adhesion mediated by LFA-1.
This article has been cited by other articles:
|
|
 |
|
  S. M. Wood, M. Meeths, S. C. C. Chiang, A. G. Bechensteen, J. J. Boelens, C. Heilmann, H. Horiuchi, S. Rosthoj, O. Rutynowska, J. Winiarski, et al. Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity Blood, November 5, 2009; 114(19): 4117 - 4127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. T. Bryceson, H.-G. Ljunggren, and E. O. Long Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors Blood, September 24, 2009; 114(13): 2657 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Jones, J. C. D. Wiseman, K. J. Marr, S. Wei, J. Y. Djeu, and C. H. Mody In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1 Int. Immunol., April 1, 2009; 21(4): 423 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Pallandre, K. Krzewski, R. Bedel, B. Ryffel, A. Caignard, P. S. Rohrlich, X. Pivot, P. Tiberghien, L. Zitvogel, J. L. Strominger, et al. Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation Blood, December 1, 2008; 112(12): 4420 - 4424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Banerjee, G. Feuer, and E. Barker Human T-Cell Leukemia Virus Type 1 (HTLV-1) p12I Down-Modulates ICAM-1 and -2 and Reduces Adherence of Natural Killer Cells, Thereby Protecting HTLV-1-Infected Primary CD4+ T Cells from Autologous Natural Killer Cell-Mediated Cytotoxicity despite the Reduction of Major Histocompatibility Complex Class I Molecules on Infected Cells J. Virol., September 15, 2007; 81(18): 9707 - 9717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Munitz, I. Bachelet, F. D. Finkelman, M. E. Rothenberg, and F. Levi-Schaffer CD48 Is Critically Involved in Allergic Eosinophilic Airway Inflammation Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 911 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Osman, D. N. Burshtyn, and K. P. Kane Activating Ly-49 Receptors Regulate LFA-1-Mediated Adhesion by NK Cells J. Immunol., February 1, 2007; 178(3): 1261 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abdool, E. Cretney, A. D. Brooks, J. M. Kelly, J. Swann, A. Shanker, E. W. Bere Jr., W. M. Yokoyama, J. R. Ortaldo, M. J. Smyth, et al. NK Cells Use NKG2D to Recognize a Mouse Renal Cancer (Renca), yet Require Intercellular Adhesion Molecule-1 Expression on the Tumor Cells for Optimal Perforin-Dependent Effector Function J. Immunol., August 15, 2006; 177(4): 2575 - 2583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Fostel, J. Dluzniewska, Y. Shimizu, B. J. Burbach, and E. J. Peterson ADAP is dispensable for NK cell development and function Int. Immunol., August 1, 2006; 18(8): 1305 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koneru, N. Monu, D. Schaer, J. Barletta, and A. B. Frey Defective Adhesion in Tumor Infiltrating CD8+ T Cells J. Immunol., May 15, 2006; 176(10): 6103 - 6111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Le Maux Chansac, A. Moretta, I. Vergnon, P. Opolon, Y. Lecluse, D. Grunenwald, M. Kubin, J.-C. Soria, S. Chouaib, and F. Mami-Chouaib NK Cells Infiltrating a MHC Class I-Deficient Lung Adenocarcinoma Display Impaired Cytotoxic Activity toward Autologous Tumor Cells Associated with Altered NK Cell-Triggering Receptors J. Immunol., November 1, 2005; 175(9): 5790 - 5798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. T. Bryceson, M. E. March, D. F. Barber, H.-G. Ljunggren, and E. O. Long Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells J. Exp. Med., October 3, 2005; 202(7): 1001 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Arase, A. Takeuchi, M. Unno, S. Hirano, T. Yokosuka, H. Arase, and T. Saito Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells Int. Immunol., September 1, 2005; 17(9): 1227 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Boles, W. Barchet, T. Diacovo, M. Cella, and M. Colonna The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM Blood, August 1, 2005; 106(3): 779 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Roda-Navarro, M. Mittelbrunn, M. Ortega, D. Howie, C. Terhorst, F. Sanchez-Madrid, and E. Fernandez-Ruiz Dynamic Redistribution of the Activating 2B4/SAP Complex at the Cytotoxic NK Cell Immune Synapse J. Immunol., September 15, 2004; 173(6): 3640 - 3646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Barber, M. Faure, and E. O. Long LFA-1 Contributes an Early Signal for NK Cell Cytotoxicity J. Immunol., September 15, 2004; 173(6): 3653 - 3659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gismondi, L. Cifaldi, C. Mazza, S. Giliani, S. Parolini, S. Morrone, J. Jacobelli, E. Bandiera, L. Notarangelo, and A. Santoni Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect Blood, July 15, 2004; 104(2): 436 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fuchs, M. Cella, E. Giurisato, A. S. Shaw, and M. Colonna Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155) J. Immunol., April 1, 2004; 172(7): 3994 - 3998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Riteau, D. F. Barber, and E. O. Long Vav1 Phosphorylation Is Induced by {beta}2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft Reorganization J. Exp. Med., August 4, 2003; 198(3): 469 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faure, D. F. Barber, S. M. Takahashi, T. Jin, and E. O. Long Spontaneous Clustering and Tyrosine Phosphorylation of NK Cell Inhibitory Receptor Induced by Ligand Binding J. Immunol., June 15, 2003; 170(12): 6107 - 6114. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
