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* Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101; and Departments of
Pathology and
Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
IL-2 and IL-15 are thought to be important cytokines for T
cell-dependent immune responses. Mice deficient in IL-2, IL-2R
, and
IL-2R
are each characterized by a rapid lethal autoimmune
lymphoproliferative disorder that complicates their use in studies
aimed at investigating the role of these cytokines and receptors for
immune responses in vivo. We have previously characterized a novel
transgenic (Tg) mouse on the IL-2R-/- genetic
background (Tg-/- mice) that lacks autoimmune disease but
still contains peripheral T cells that are nonresponsive to IL-2 and
IL-15. In the present study, these mice were used to investigate the
extent by which IL-2 and IL-15 are essential for T cell immunity in
vivo. Tg-/- mice generated near normal primary and
secondary Ab responses to OVA, readily mounted first and second set
allogeneic skin graft rejection responses, and developed primary and
recall CD8 T cell responses to vaccinia virus. However,
Tg-/- mice generated a slightly lower level of IgG2a Abs
to OVA, exhibited a somewhat delayed first set skin graft rejection
response with lower allo-specific CTL, and developed a significantly
lower number of IFN-
-producing vaccinia-specific CD8+ T
cells. Thus, although T effector function is somewhat impaired, T cell
immunity is largely functional in the absence of IL-2- and
IL-15-induced signaling through IL-2R.
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