The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gray, P. M.
Right arrow Articles by Alexander-Miller, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gray, P. M.
Right arrow Articles by Alexander-Miller, M. A.
The Journal of Immunology, 2003, 170: 174-181.
Copyright © 2003 by The American Association of Immunologists

High Avidity CD8+ T Cells Are the Initial Population Elicited Following Viral Infection of the Respiratory Tract1

Peter M. Gray, Griffith D. Parks and Martha A. Alexander-Miller2

Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157

Following intranasal administration, the model paramyxovirus simian virus 5 (SV5) establishes an infection in the respiratory tract of mice, which is subsequently cleared by CD8+ T cells. In this study, we sought to understand the maturation of the antiviral immune response over time by assessing the functional avidity of the responding T cells and the expansion of immunodominant populations. Surprisingly, we determined that the initial response to Ag at day 3 (d3) in the mediastinal lymph node was exclusively high avidity. However, by d5 postinfection, low avidity cells were ~50% of the responding T cell population. Following secondary exposure to SV5, high avidity CD8+ T cells again are the exclusive cell type present at early times postinfection (d2). Similarly, high avidity cells were preferentially elicited at d3 following infection with the unrelated vaccinia virus. We also made the observation that the immunodominance profile has not been established at d3 postinfection with SV5. However, by d5 a clear immunodominance pattern arises and is permanently maintained. These data indicate that high avidity cells are the predominant population responding at early times postinfection following respiratory infection with SV5 or vaccinia virus. However, as the response progresses, low avidity cells are activated/expanded to a greater extent compared with high avidity cells.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
G. Plesa, A. E. Snook, S. A. Waldman, and L. C. Eisenlohr
Derivation and Fluidity of Acutely Induced Dysfunctional CD8+ T Cells
J. Immunol., April 15, 2008; 180(8): 5300 - 5308.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Arimilli, E. M. Palmer, and M. A. Alexander-Miller
Loss of function in virus-specific lung effector T cells is independent of infection
J. Leukoc. Biol., March 1, 2008; 83(3): 564 - 574.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Z. Xiao, M. F. Mescher, and S. C. Jameson
Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation
J. Exp. Med., October 29, 2007; 204(11): 2667 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
G. Plesa, P. M. McKenna, M. J. Schnell, and L. C. Eisenlohr
Immunogenicity of cytopathic and noncytopathic viral vectors.
J. Virol., July 1, 2006; 80(13): 6259 - 6266.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. C. M. Boon, G. de Mutsert, R. A. M. Fouchier, A. D. M. E. Osterhaus, and G. F. Rimmelzwaan
The Hypervariable Immunodominant NP418-426 Epitope from the Influenza A Virus Nucleoprotein Is Recognized by Cytotoxic T Lymphocytes with High Functional Avidity.
J. Virol., June 1, 2006; 80(12): 6024 - 6032.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P. M. Lavoie, A. R. Dumont, H. McGrath, A.-E. Kernaleguen, and R.-P. Sekaly
Delayed expansion of a restricted T cell repertoire by low-density TCR ligands
Int. Immunol., July 1, 2005; 17(7): 931 - 941.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. S. Pejawar, G. D. Parks, and M. A. Alexander-Miller
Abortive versus Productive Viral Infection of Dendritic Cells with a Paramyxovirus Results in Differential Upregulation of Select Costimulatory Molecules
J. Virol., June 15, 2005; 79(12): 7544 - 7557.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. M. Gray, S. Arimilli, E. M. Palmer, G. D. Parks, and M. A. Alexander-Miller
Altered Function in CD8+ T Cells following Paramyxovirus Infection of the Respiratory Tract
J. Virol., March 15, 2005; 79(6): 3339 - 3349.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. L. La Gruta, S. J. Turner, and P. C. Doherty
Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity
J. Immunol., May 1, 2004; 172(9): 5553 - 5560.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.