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Cutting Edge |
Department of Academic Surgery, National University of Ireland, Cork University Hospital, Cork, Ireland
Tolerance to bacterial cell wall components is an adaptive host
response. Endotoxin/LPS tolerance is characterized by a survival
advantage against subsequent lethal LPS challenge. However, it is
uncertain whether LPS tolerance can afford protection against other
septic challenges. In this study, we show that tolerance induced by
bacterial lipoprotein (BLP) protects mice against not only BLP-induced
lethality, but also LPS-, live bacteria-, and polymicrobial
sepsis-induced lethality. In contrast, LPS tolerance offers no survival
benefit against the latter two challenges. Furthermore, induction of
BLP tolerance results in overexpression of complement receptor type 3
and Fc
III/IIR on neutrophils (polymorphonuclear neutrophils)
and peritoneal macrophages, with increased bacterial recognition and
bactericidal activity, whereas LPS-tolerized mice exhibit an impaired
ability to ingest and to kill bacteria. These results indicate that BLP
tolerance is a novel adaptive host response associated with a unique
protective effect during septic shock.
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