The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gao, W.
Right arrow Articles by Gambotto, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, W.
Right arrow Articles by Gambotto, A.
The Journal of Immunology, 2003, 170: 107-113.
Copyright © 2003 by The American Association of Immunologists

Innate Immunity Mediated by the Cytokine IL-1 Homologue 4 (IL-1H4/IL-1F7) Induces IL-12-Dependent Adaptive and Profound Antitumor Immunity1

Wentao Gao*, Sanjay Kumar{ddagger}, Michael T. Lotze*,{dagger},{ddagger}, Charles Hanning{ddagger}, Paul D. Robbins* and Andrea Gambotto2,*,{dagger}

* Departments of Molecular Genetics and Biochemistry and {dagger} Surgery, University of Pittsburgh, PA 15219; and {ddagger} Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406

Recently, several novel members of the IL-1 family have been identified. The possible therapeutic utility and the underlying biologic role of these new members remain unclear. In the present study we analyzed the anti-tumor activity of human IL-1 homologue 4(IL-1H4; renamed IL-F7) by adenovirus-mediated gene transfer (AdIL-1H4) directly into murine tumors. In vitro expression analysis showed that IL-1H4 was a secretory protein. Treatment of an established MCA205 mouse fibrosarcoma by single intratumoral injection of AdIL-1H4 resulted in significant growth suppression. Furthermore, complete inhibition of tumor growth was observed following multiple injections of AdIL-1H4. The anti-tumor activity of IL-1H4 was abrogated in nude and SCID mice and in IL-12-, IFN-{gamma}-, or Fas ligand-deficient mice. In contrast, IL-1H4 was able to confer substantial anti-tumor effects in NKT-deficient mice. These results suggest that IL-1H4 could play an important role in the link between innate and adaptive immunity and may be useful for tumor immunotherapy.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. Sharma, N. Kulk, M. F. Nold, R. Graf, S.-H. Kim, D. Reinhardt, C. A. Dinarello, and P. Bufler
The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines
J. Immunol., April 15, 2008; 180(8): 5477 - 5482.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Kuwashima, F. Nishimura, J. Eguchi, H. Sato, M. Hatano, T. Tsugawa, T. Sakaida, J. E. Dusak, W. K. Fellows-Mayle, G. D. Papworth, et al.
Delivery of Dendritic Cells Engineered to Secrete IFN-{alpha} into Central Nervous System Tumors Enhances the Efficacy of Peripheral Tumor Cell Vaccines: Dependence on Apoptotic Pathways
J. Immunol., August 15, 2005; 175(4): 2730 - 2740.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. E. Towne, K. E. Garka, B. R. Renshaw, G. D. Virca, and J. E. Sims
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-{kappa}B and MAPKs
J. Biol. Chem., April 2, 2004; 279(14): 13677 - 13688.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2003 by The American Association of Immunologists, Inc. All rights reserved.