HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Roberts, E. F. Search for Related Content PubMed Articles by Roberts, E. F.

The Reticulo-Endothelial System and Antibody Production

II. The Disappearance of Antigen from the Circulation¹

Department of Immunology, Yale University School of Medicine, New Haven Connecticut

Abstract

In a previous study (5) consideration was given to the influence of a reticulo-endothelial blockade upon the appearance of antibody in the circulating blood of the rabbit injected with antigens of various types. India ink, diluted in distilled H₂O and filtered, was found to qualify as a suitable blockading agent since the carbon particles were intensely phagocytized and the mechanical barrier thus effected persisted for a considerable length of time. Various types of antigen were employed singly and in combination. Most significant of all, the study revealed that the results derived from a given experiment of this kind might suggest an interpretation in a definite direction whereas the results secured in a second experiment, carried out under almost identical conditions, could only be interpreted in an entirely different way. Moreover, the disagreement in results of duplicate experiments was not surpassed by the varied observations of workers who, compared one with the other, conducted their experiments under far more dissimilar conditions.

Footnotes

¹ This paper forms part of a thesis presented to Yale University in candidacy for the degree of Doctor of Philosophy.