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Anaphylaxis

XI. Physiological Studies of the Hypersensitive Rabbit¹

From the Department of Bacteriology, University of Kansas, Lawrence

Abstract

Among immunologists the rabbit has enjoyed considerable popularity as an experimental animal, but for some unknown reason has not been used in anaphylactic studies as extensively as some other animals—dogs and guinea pigs. This situation has probably been fostered by statements and inferences in the literature that the rabbit is very difficult to sensitize, and that the usual criteria used to denote sensitization among other species give rather variable and inconclusive results when applied to the rabbit.

Auer (1) states that rabbits are not so easily prepared, nor can as high a degree of sensitization be obtained as readily and as certainly as in the guinea pig. He suggests that of various methods employed to sensitize rabbits, perhaps some modification of the Arthus method—4 to 8 injections of antigen subcutaneously 4 to 8 days apart—is the best. He also quotes Arthus as finding the incubation period from 8 to 15 days after the last injection.

Footnotes

¹ Submitted to the Department of Bacteriology and the Faculty of the Graduate School in partial fulfillment of the requirements for the degree of Doctor of Philosophy.