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T Cell Subsets Express Distinct Patterns of Chemokine Responsiveness and Adhesion Molecules: A Mechanism for Tissue-Specific T Cell Subset Accumulation1
* Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304;
Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717; and
Millennium Pharmaceuticals, Cambridge, MA 02139
Subsets of 
T cells localize to distinct tissue sites
in the absence of exogenous Ag stimulation or development of
effector/memory cells. Selective lymphocyte homing from the blood into
tissues is controlled by a multistep process involving vascular and
lymphocyte adhesion molecules, and G protein-linked chemokine
receptors. The role of these mechanisms in the tissue tropism of
T cells is still poorly understood. In this study, we demonstrate that
a subset of T cells, most of which express an antigenically
distinct TCR and are characterized by coexpression of CD8, selectively
accumulated in tissues that expressed high levels of the mucosal
vascular addressin, mucosal addressin cell adhesion molecule 1.
These cells expressed higher levels of 
4
7
integrins than other T cell subsets and selectively migrated to
the CCR7 ligand secondary lymphoid-tissue chemokine (CCL21).
Integrin activation by CCL21 selectively increased
CD8+ T cell binding to recombinant mucosal addressin
cell adhesion molecule 1. These results suggest that the tropism of
circulating CD8+ T cells for mucosal tissues is due,
at least in part, to selective developmental expression of adhesion
molecules and chemokine receptors.
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