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The Journal of Immunology, 2002, 169: 4882-4888.
Copyright © 2002 by The American Association of Immunologists

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-11

Hyeon-Woo Lee*, Su-Jung Park*, Beom K. Choi*, Hyun Hwa Kim*, Kyung-Ok Nam* and Byoung S. Kwon2,*,{dagger}

* Immunomodulation Research Center, University of Ulsan, Ulsan, Korea; and {dagger} Louisiana State University Eye Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112

4-1BB, a T cell costimulatory receptor, prolongs CD8+ T cell survival. In these studies, 4-1BB stimulation was shown to increase expression of the antiapoptotic genes bcl-xL and bfl-1 via 4-1BB-mediated NF-{kappa}B activation. This signaling pathway was specifically inhibited by PDTC and was different from the pathways that enhanced CD8+ T cell proliferation. The results suggest a role for the antiapoptotic activities of Bcl-xL and Bfl-1 proteins in 4-1BB-mediated CD8+ T cell survival in vivo.




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