The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Asai, K.
Right arrow Articles by Kaminogawa, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asai, K.
Right arrow Articles by Kaminogawa, S.
The Journal of Immunology, 2002, 169: 4723-4731.
Copyright © 2002 by The American Association of Immunologists

T Cell Hyporesponsiveness Induced by Oral Administration of Ovalbumin Is Associated with Impaired NFAT Nuclear Translocation and p27kip1 Degradation

Kazumi Asai1,*, Satoshi Hachimura2,*, Motoko Kimura{dagger}, Terumasa Toraya*, Masakatsu Yamashita{dagger}, Toshinori Nakayama{dagger} and Shuichi Kaminogawa*

* Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan; and {dagger} Departments of Medical Immunology and Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan

Oral tolerance is an important physiological component of the immune system whereby the organism avoids dangerous reactions such as hypersensitivity to ingested food proteins and other luminal Ags which may cause tissue damage and inflammation. In addition, it has been shown in animal models and in humans that oral tolerance can be applied to controlling undesired immune responses, including autoimmune diseases, allergies, and organ transplant rejections. However, the molecular mechanisms of oral tolerance have been poorly defined. In this study, we investigated the molecular basis underlying the hyporesponsiveness of orally tolerant CD4 T cells using a TCR transgenic mouse system in which oral tolerance was induced by long-term feeding with high dose Ag. We demonstrate that the hyporesponsive state of the CD4 T cells was maintained by a selective impairment in the TCR-induced calcium/NFAT signaling pathway and in the IL-2R-induced degradation of p27kip1 and cell cycle progression. Thus, physiological mucosal tolerance is revealed to be associated with a unique type of T cell hyporesponsiveness which differs from previously described anergic T cells.




This article has been cited by other articles:


Home page
 BloodHome page
I. A. Parish, S. Rao, G. K. Smyth, T. Juelich, G. S. Denyer, G. M. Davey, A. Strasser, and W. R. Heath
The molecular signature of CD8+ T cells undergoing deletional tolerance
Blood, May 7, 2009; 113(19): 4575 - 4585.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Srinivasan and K. A. Frauwirth
Reciprocal NFAT1 and NFAT2 Nuclear Localization in CD8+ Anergic T Cells Is Regulated by Suboptimal Calcium Signaling
J. Immunol., September 15, 2007; 179(6): 3734 - 3741.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. A. Rowell, L. Wang, W. W. Hancock, and A. D. Wells
The Cyclin-Dependent Kinase Inhibitor p27kip1 Is Required for Transplantation Tolerance Induced by Costimulatory Blockade
J. Immunol., October 15, 2006; 177(8): 5169 - 5176.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P.-Y. Mantel, N. Ouaked, B. Ruckert, C. Karagiannidis, R. Welz, K. Blaser, and C. B. Schmidt-Weber
Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells
J. Immunol., March 15, 2006; 176(6): 3593 - 3602.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Chiodetti, S. Choi, D. L. Barber, and R. H. Schwartz
Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States
J. Immunol., February 15, 2006; 176(4): 2279 - 2291.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Ise, K. Nakamura, N. Shimizu, H. Goto, K. Fujimoto, S. Kaminogawa, and S. Hachimura
Orally Tolerized T Cells Can Form Conjugates with APCs but Are Defective in Immunological Synapse Formation
J. Immunol., July 15, 2005; 175(2): 829 - 838.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. O. Anderson, A. Sundstedt, Z. Yazici, S. Minaee, R. Woolf, K. Nicolson, N. Whitley, L. Li, S. Li, D. C. Wraith, et al.
IL-2 Overcomes the Unresponsiveness but Fails to Reverse the Regulatory Function of Antigen-Induced T Regulatory Cells
J. Immunol., January 1, 2005; 174(1): 310 - 319.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. L. Adams, A. M. Grierson, A. M. Mowat, M. M. Harnett, and P. Garside
Differences in the Kinetics, Amplitude, and Localization of ERK Activation in Anergy and Priming Revealed at the Level of Individual Primary T Cells by Laser Scanning Cytometry
J. Immunol., August 1, 2004; 173(3): 1579 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Schwarz, E. Tutsch, B. Ludwig, E. C. Schwarz, A. Stallmach, and M. Hoth
Ca2+ Signaling in Identified T-lymphocytes from Human Intestinal Mucosa: RELATION TO HYPOREACTIVITY, PROLIFERATION, AND INFLAMMATORY BOWEL DISEASE
J. Biol. Chem., February 13, 2004; 279(7): 5641 - 5647.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kaji, S. Hachimura, W. Ise, and S. Kaminogawa
Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4 T Lymphocytes Induced in Vivo by the Oral Administration of Antigen
J. Biol. Chem., July 18, 2003; 278(30): 27836 - 27843.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.