| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
* Molecular Immunology and
Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; and Departments of
Pathology and
Immunology, Juntendo University School of Medicine, Tokyo, Japan
B7 homologous protein (B7h)/B7-related protein 1 (B7RP-1) is a new
member of the B7 family of costimulatory molecules that specifically
interacts with inducible costimulator (ICOS) expressed on activated T
cells. Collagen type II (CII)-induced arthritis (CIA) is an
experimental model of arthritis that has been used to dissect the
pathogenesis of human rheumatoid arthritis. In this study, we have
investigated the effect of neutralizing anti-B7h mAb on the
development and disease progression of CIA. Administration of
anti-B7h mAb significantly ameliorated the disease as assessed by
clinical arthritis score and histology in the joints, and a beneficial
effect was also obtained by a delayed treatment after the onset of
disease. Expression of ICOS and B7h was observed in the inflamed
synovial tissue as well as in the draining lymph nodes (LNs) and
expansion of ICOS+ T cells in the LN was reduced by the
anti-B7h mAb treatment. Expression of mRNA for proinflammatory
cytokines such as TNF-
, IL-1
, and IL-6 in the joints was
inhibited by the treatment. Proliferative responses and production of
IFN-
and IL-10 upon restimulation with CII in vitro were
significantly inhibited in LN cells from the anti-B7h mAb-treated
mice. Serum anti-CII IgG1, IgG2a, and IgG2b levels were also
reduced. Our present results showed a beneficial effect of the B7h
blockade on CIA through anti-inflammatory actions and inhibition of
both Th1- and Th2-mediated immune responses, suggesting that the
ICOS-B7h interaction plays an important role in the pathogenesis of CIA
and thus the blockade of this pathway may be beneficial for the
treatment of human rheumatoid arthritis.
This article has been cited by other articles:
|
|
 |
|
  N. Takahashi, K. Matsumoto, H. Saito, T. Nanki, N. Miyasaka, T. Kobata, M. Azuma, S.-K. Lee, S. Mizutani, and T. Morio Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients J. Immunol., May 1, 2009; 182(9): 5515 - 5527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Odegard, L. D. DiPlacido, L. Greenwald, M. Kashgarian, D. H. Kono, C. Dong, R. A. Flavell, and J. Craft ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus J. Immunol., April 1, 2009; 182(7): 4076 - 4084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Hu, D. P. Metz, J. Chung, G. Siu, and M. Zhang B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells J. Immunol., February 1, 2009; 182(3): 1421 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Chen, J. L. Cannons, J. C. Paton, H. Akiba, P. L. Schwartzberg, and C. M. Snapper A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine J. Immunol., December 15, 2008; 181(12): 8258 - 8266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nagashima, N. Harada, Y. Usui, T. Yamazaki, H. Yagita, K. Okumura, K. Takahashi, and H. Akiba B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma J. Immunol., September 15, 2008; 181(6): 4062 - 4071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Peng, P. Ye, B. R. Blazar, G. J. Freeman, D. J. Rawlings, H. D. Ochs, and C. H. Miao Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice Blood, September 1, 2008; 112(5): 1662 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watanabe, Y. Takagi, M. Kotani, Y. Hara, A. Inamine, K. Hayashi, S. Ogawa, K. Takeda, K. Tanabe, and R. Abe Down-Regulation of ICOS Ligand by Interaction with ICOS Functions as a Regulatory Mechanism for Immune Responses J. Immunol., April 15, 2008; 180(8): 5222 - 5234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Rojo, E. Pini, G. Ojeda, R. Bello, C. Dong, R. A. Flavell, U. Dianzani, and P. Portoles CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo' Int. Immunol., April 1, 2008; 20(4): 577 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hawiger, E. Tran, W. Du, C. J. Booth, L. Wen, C. Dong, and R. A. Flavell ICOS Mediates the Development of Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice J. Immunol., March 1, 2008; 180(5): 3140 - 3147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H.-M. Tan, S. Y.-P. Goh, S.-C. Wong, and K.-P. Lam T Helper Cell-specific Regulation of Inducible Costimulator Expression via Distinct Mechanisms Mediated by T-bet and GATA-3 J. Biol. Chem., January 4, 2008; 283(1): 128 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. O'Neill, Y. Cao, K. M. Hamel, P. D. Doodes, G. Hutas, and A. Finnegan Expression of CD80/86 on B Cells Is Essential for Autoreactive T Cell Activation and the Development of Arthritis J. Immunol., October 15, 2007; 179(8): 5109 - 5116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Katsumata, M. Harigai, T. Sugiura, M. Kawamoto, Y. Kawaguchi, Y. Matsumoto, K. Kohyama, M. Soejima, N. Kamatani, and M. Hara Attenuation of Experimental Autoimmune Myositis by Blocking ICOS-ICOS Ligand Interaction J. Immunol., September 15, 2007; 179(6): 3772 - 3779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kamata, S. Kamijo, A. Nakajima, A. Koyanagi, H. Kurosawa, H. Yagita, and K. Okumura Involvement of TNF-Like Weak Inducer of Apoptosis in the Pathogenesis of Collagen-Induced Arthritis J. Immunol., November 1, 2006; 177(9): 6433 - 6439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Odobasic, A. R. Kitching, T. J. Semple, and S. R. Holdsworth Inducible Co-Stimulatory Molecule Ligand Is Protective during the Induction and Effector Phases of Crescentic Glomerulonephritis J. Am. Soc. Nephrol., April 1, 2006; 17(4): 1044 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Hubbard, J. M. Eng, T. Ramirez-Montagut, K. H. Tjoe, S. J. Muriglan, A. A. Kochman, T. H. Terwey, L. M. Willis, R. Schiro, G. Heller, et al. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation Blood, November 1, 2005; 106(9): 3285 - 3292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akiba, K. Takeda, Y. Kojima, Y. Usui, N. Harada, T. Yamazaki, J. Ma, K. Tezuka, H. Yagita, and K. Okumura The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo J. Immunol., August 15, 2005; 175(4): 2340 - 2348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tsukahara, M. Takeuchi, H. Akiba, T. Kezuka, K. Takeda, Y. Usui, M. Usui, H. Yagita, and K. Okumura Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation Int. Immunol., May 1, 2005; 17(5): 523 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Watanabe, Y. Hara, K. Tanabe, H. Toma, and R. Abe A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets Int. Immunol., March 1, 2005; 17(3): 269 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kohyama, D. Sugahara, S. Sugiyama, H. Yagita, K. Okumura, and N. Hozumi Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen PNAS, March 23, 2004; 101(12): 4192 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Demirci, F. Amanullah, R. Kewalaramani, H. Yagita, T. B. Strom, M. H. Sayegh, and X. C. Li Critical Role of OX40 in CD28 and CD154-Independent Rejection J. Immunol., February 1, 2004; 172(3): 1691 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Iwai, M. Abe, S. Hirose, F. Tsushima, K. Tezuka, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, et al. Involvement of Inducible Costimulator-B7 Homologous Protein Costimulatory Pathway in Murine Lupus Nephritis J. Immunol., September 15, 2003; 171(6): 2848 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Vermaelen and R. Pauwels Accelerated Airway Dendritic Cell Maturation, Trafficking, and Elimination in a Mouse Model of Asthma Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 405 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Futamatsu, J.-i. Suzuki, H. Kosuge, O. Yokoseki, M. Kamada, H. Ito, M. Inobe, M. Isobe, and T. Uede Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway Cardiovasc Res, July 1, 2003; 59(1): 95 - 104. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
