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, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection1
* Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912;
Department of Internal Medicine, Ohio State University, Columbus, OH 43210;
Department of Immunology, University of Glasgow, Glasgow, United Kingdom; and
Department of Pathology, Children’s Hospital and Research Institute, Columbus, OH 43205
NK cell cytotoxicity, IFN-
expression, proliferation, and
accumulation are rapidly induced after murine CMV infections.
Under these conditions, the responses were shown to be elicited in
overlapping populations. Nevertheless, there were distinct signaling
molecule requirements for induction of functions within the subsets.
IL-12/STAT4 was critical for NK cell IFN- expression, whereas
IFN-
/STAT1 were required for induction of cytotoxicity. The
accumulation/survival of proliferating NK cells was STAT4-independent
but required IFN-/STAT1 induction of IL-15. Taken together, the
results define the coordinated interactions between the cytokines
IFN-, IL-12, and IL-15 for activation of protective NK cell
responses during viral infections, and emphasize these factors’
nonredundant functions under in vivo physiological
conditions.
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 M. J. Loza and B. Perussia Differential regulation of NK cell proliferation by type I and type II IFN Int. Immunol., January 1, 2004; 16(1): 23 - 32. [Abstract] [Full Text] [PDF]
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M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, V. Groh, T. Spies, T. Suzuki, T. Miyagi, and N. Hayashi Autocrine/Paracrine IL-15 That Is Required for Type I IFN-Mediated Dendritic Cell Expression of MHC Class I-Related Chain A and B Is Impaired in Hepatitis C Virus Infection J. Immunol., November 15, 2003; 171(10): 5423 - 5429. [Abstract] [Full Text] [PDF]
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T. Ranson, C. A. J. Vosshenrich, E. Corcuff, O. Richard, W. Muller, and J. P. Di Santo IL-15 is an essential mediator of peripheral NK-cell homeostasis Blood, June 15, 2003; 101(12): 4887 - 4893. [Abstract] [Full Text] [PDF]
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M. Dalod, T. Hamilton, R. Salomon, T. P. Salazar-Mather, S. C. Henry, J. D. Hamilton, and C. A. Biron Dendritic Cell Responses to Early Murine Cytomegalovirus Infection: Subset Functional Specialization and Differential Regulation by Interferon {alpha}/{beta} J. Exp. Med., April 7, 2003; 197(7): 885 - 898. [Abstract] [Full Text] [PDF]
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K. Abel, L. Compton, T. Rourke, D. Montefiori, D. Lu, K. Rothaeusler, L. Fritts, K. Bost, and C. J. Miller Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses J. Virol., March 1, 2003; 77(5): 3099 - 3118. [Abstract] [Full Text] [PDF]
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