| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
* Immunology, and
Otorhinolaryngology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905
NK cells possess both effector and regulatory activities that may
be important during the antitumor immune response. In fact, the
generation of antitumor immunity by the administration of an agonistic
mAb against CD137 is NK cell-dependent. In this study, we report that
NK cells could be induced by IL-2 and IL-15 to express CD137 and
ligation of CD137-stimulated NK cell proliferation and IFN-
secretion, but not their cytolytic activity. Importantly,
CD137-stimulated NK cells promoted the expansion of activated T cells
in vitro, demonstrating immunoregulatory or "helper" activity for
CD8+CTL. Furthermore, tumor-specific CTL activity against
P815 tumor Ags was abrogated following anti-CD137 treatment in
NK-depleted mice. We further demonstrate that CD137-stimulated helper
NK cells expressed the high-affinity IL-2R and were hyperresponsive to
IL-2. Taken together with previous findings that CD137 is a critical
receptor for costimulation of T cells, our findings suggest that CD137
is a stimulatory receptor for NK cells involved in the crosstalk
between innate and adaptive immunity.
This article has been cited by other articles:
|
|
 |
|
  X. Yan, B. D. Johnson, and R. J. Orentas Induction of a VLA-2 (CD49b)-Expressing Effector T Cell Population by a Cell-Based Neuroblastoma Vaccine Expressing CD137L J. Immunol., October 1, 2008; 181(7): 4621 - 4631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Lin, C. J. Voskens, X. Zhang, D. G. Schindler, A. Wood, E. Burch, Y. Wei, L. Chen, G. Tian, K. Tamada, et al. Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies Blood, August 1, 2008; 112(3): 699 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Lee, R. J. Rossi, S.-K. Lee, M. Croft, B. S. Kwon, R. S. Mittler, and A. T. Vella CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent J. Immunol., August 15, 2007; 179(4): 2203 - 2214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Zhang, R. E. Sadun, R. S. Arias, M. L. Flanagan, S. M. Sachsman, Y.-C. Nien, L. A. Khawli, P. Hu, and A. L. Epstein Targeted and Untargeted CD137L Fusion Proteins for the Immunotherapy of Experimental Solid Tumors Clin. Cancer Res., May 1, 2007; 13(9): 2758 - 2767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Houtenbos, T. M. Westers, A. Dijkhuis, T. D. de Gruijl, G. J. Ossenkoppele, and A. A. van de Loosdrecht Leukemia-Specific T-Cell Reactivity Induced by Leukemic Dendritic Cells Is Augmented by 4-1BB Targeting Clin. Cancer Res., January 1, 2007; 13(1): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Lee, Y. Park, A. Song, H. Cheroutre, B. S. Kwon, and M. Croft Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses J. Immunol., October 1, 2006; 177(7): 4464 - 4472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, S. E. Blink, W. Liu, Y. Lee, B. Chen, J. Solway, J. Weinstock, L. Chen, and Y.-X. Fu Inhibition of Th2-Mediated Allergic Airway Inflammatory Disease by CD137 Costimulation J. Immunol., July 15, 2006; 177(2): 814 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bukczynski, T. Wen, C. Wang, N. Christie, J.-P. Routy, M.-R. Boulassel, C. M. Kovacs, K. S. MacDonald, M. Ostrowski, R.-P. Sekaly, et al. Enhancement of HIV-Specific CD8 T Cell Responses by Dual Costimulation with CD80 and CD137L J. Immunol., November 15, 2005; 175(10): 6378 - 6389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Lee, A. T. Vella, B. S. Kwon, and M. Croft Enhanced CD4 T Cell Responsiveness in the Absence of 4-1BB J. Immunol., June 1, 2005; 174(11): 6803 - 6808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ito, Q. Li, A. B. Shreiner, R. Okuyama, M. N. Jure-Kunkel, S. Teitz-Tennenbaum, and A. E. Chang Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines Cancer Res., November 15, 2004; 64(22): 8411 - 8419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Vinay, B. K. Choi, J. S. Bae, W. Y. Kim, B. M. Gebhardt, and B. S. Kwon CD137-Deficient Mice Have Reduced NK/NKT Cell Numbers and Function, Are Resistant to Lipopolysaccharide-Induced Shock Syndromes, and Have Lower IL-4 Responses J. Immunol., September 15, 2004; 173(6): 4218 - 4229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Vankayalapati, P. Klucar, B. Wizel, S. E. Weis, B. Samten, H. Safi, H. Shams, and P. F. Barnes NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen J. Immunol., January 1, 2004; 172(1): 130 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Wilcox, K. Tamada, D. B. Flies, G. Zhu, A. I. Chapoval, B. R. Blazar, W. M. Kast, and L. Chen Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo Blood, January 1, 2004; 103(1): 177 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Murillo, A. Arina, I. Tirapu, C. Alfaro, G. Mazzolini, B. Palencia, A. L.-D. De Cerio, J. Prieto, M. Bendandi, and I. Melero Potentiation of Therapeutic Immune Responses against Malignancies with Monoclonal Antibodies Clin. Cancer Res., November 15, 2003; 9(15): 5454 - 5464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Melero, I. Gabari, I. Tirapu, A. Arina, G. Mazzolini, E. Baixeras, E. Feijoo, C. Alfaro, C. Qian, and J. Prieto Anti-ICAM-2 Monoclonal Antibody Synergizes with Intratumor Gene Transfer of Interleukin-12 Inhibiting Activation-induced T-Cell Death Clin. Cancer Res., September 1, 2003; 9(10): 3546 - 3554. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
