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-Chain-Deficient Mice1
Departments of
* Dermatology and
Immunology, Niigata University School of Medicine, Niigata, Japan; and
Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305
IL-2/IL-15R
-deficient mice display impaired development of NK
cells, NKT cells, and intraepithelial lymphocytes of the intestine and
skin. To determine the role of survival signals mediated by IL-2/IL-15R
in the development of these innate lymphocytes, we introduced a
bcl-2 transgene into IL-2/IL-15R-deficient mice.
Enforced expression of Bcl-2 restored the number of NK cells in
IL-2/IL-15R-deficient mice, but the rescued NK cells showed no
cytotoxic activity. The numbers of NKT cells and intestinal
intraepithelial lymphocytes did not increase significantly, and skin
intraepithelial lymphocytes remained undetectable in the
bcl-2 transgenic IL-2/IL-15R-deficient mice. These
results indicate an essential role of IL-2/IL-15R-mediated survival
signals in the development of NK cells, but they also show that
additional nonsurvival signals from IL-2/IL-15R are necessary for
innate lymphocyte development.
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