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Cutting Edge |
* Department of Immunology, Tokyo Metropolitan Institute of Medical Science, and
Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
The development of Th subset is accompanied by subset-specific
chromatin remodeling of cytokine gene loci. In this study, we show that
the C-terminal, but not the N-terminal zinc finger (N-finger) of GATA-3
mediates the association with the IL-4/IL-13 intergenic DNase I
hypersensitive site and the induction of an extended DNase I
hypersensitivity on the IL-4/IL-13 locus. Consistently, deletion of the
transactivation domains or the C-finger, but not the N-finger,
abrogated the induction of IL-4 and IL-13 as well as the
down-regulation of IFN-
. In contrast, the N-finger of GATA-3 was
indispensable for the binding to the IL-5 promoter and the induction of
IL-5. The selective use of the N-finger may underlie the differential
roles of GATA-3 in the induction of IL-4, IL-13, and
IL-5.
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