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Cutting Edge |
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Walther Cancer Institute, Indianapolis, IN 46202
Pellino is a Drosophila protein originally
isolated in a two-hybrid screen for proteins interacting with the
serine/threonine kinase, pelle. Although mammalian homologs have been
identified in mouse and man, the function of pellino is as yet unknown.
In this study, the cloning, expression pattern, and a preliminary
characterization of mouse pellino-2 is described. These studies reveal
that mouse pellino-2 is expressed during embryogenesis and in a
tissue-restricted manner in the adult. IL-1 induces the association of
mouse pellino-2 with the mouse pelle-like kinase/IL-1R-associated
kinase protein, a mammalian homolog of pelle. Ectopic pellino-2
expression did not result in NF-
B activation. However, ectopic
expression of a mouse pellino-2 antisense construct inhibited IL-1 or
LPS-induced activation of NF-B-dependent IL-8 promoter activity. Our
data reveal that mouse pellino-2 is a tissue-restricted component of a
signaling pathway that couples the mouse pelle-like
kinase/IL-1R-associated kinase protein to IL-1- or LPS-dependent
signaling.
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  H. Xiao, W. Qian, K. Staschke, Y. Qian, G. Cui, L. Deng, M. Ehsani, X. Wang, Y.-W. Qian, Z. J. Chen, et al. Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NF{kappa}B Activation J. Biol. Chem., May 23, 2008; 283(21): 14654 - 14664. [Abstract] [Full Text] [PDF]
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M. P. Butler, J. A. Hanly, and P. N. Moynagh Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family: DIRECT EVIDENCE FOR PELLINO PROTEINS BEING UBIQUITIN-PROTEIN ISOPEPTIDE LIGASES J. Biol. Chem., October 12, 2007; 282(41): 29729 - 29737. [Abstract] [Full Text] [PDF]
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Z. Jiang, H. J. Johnson, H. Nie, J. Qin, T. A. Bird, and X. Li Pellino 1 Is Required for Interleukin-1 (IL-1)-mediated Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex J. Biol. Chem., March 21, 2003; 278(13): 10952 - 10956. [Abstract] [Full Text] [PDF]
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