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The Journal of Immunology, 2002, 169: 3876-3882.
Copyright © 2002 by The American Association of Immunologists

The {beta}-Glucan Receptor, Dectin-1, Is Predominantly Expressed on the Surface of Cells of the Monocyte/Macrophage and Neutrophil Lineages1

Philip R. Taylor2,*, Gordon D. Brown2,3,*, Delyth M. Reid{dagger}, Janet A. Willment*, Luisa Martinez-Pomares*, Siamon Gordon* and Simon Y. C. Wong{dagger}

* Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom; and {dagger} The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom

We recently identified dectin-1 ({beta}GR) as a major {beta}-glucan receptor on leukocytes and demonstrated that it played a significant role in the non-opsonic recognition of soluble and particulate {beta}-glucans. Using a novel mAb (2A11) raised against {beta}GR, we show here that the receptor is not dendritic cell-restricted as first reported, but is broadly expressed, with highest surface expression on populations of myeloid cells (monocyte/macrophage (M{phi}) and neutrophil lineages). Dendritic cells and a subpopulation of T cells also expressed the {beta}GR, but at lower levels. Alveolar M{phi}, like inflammatory M{phi}, exhibited the highest surface expression of {beta}GR, indicative of a role for this receptor in immune surveillance. In contrast, resident peritoneal M{phi} expressed much lower levels of {beta}GR on the cell surface. Characterization of the nonopsonic recognition of zymosan by resident peritoneal M{phi} suggested the existence of an additional {beta}-glucan-independent mechanism of zymosan binding that was not observed on elicited or bone marrow-derived M{phi}. Although this recognition could be inhibited by mannan, we were able to exclude involvement of the M{phi} mannose receptor and complement receptor 3 in this process. These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal M{phi}.




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