The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lutz, M. B.
Right arrow Articles by Gessner, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lutz, M. B.
Right arrow Articles by Gessner, A.
The Journal of Immunology, 2002, 169: 3574-3580.
Copyright © 2002 by The American Association of Immunologists

Differential Functions of IL-4 Receptor Types I and II for Dendritic Cell Maturation and IL-12 Production and Their Dependency on GM-CSF1

Manfred B. Lutz2,*, Markus Schnare{dagger}, Mauritius Menges*, Susanne Rössner*, Martin Röllinghoff{dagger}, Gerold Schuler* and André Gessner{dagger}

* Department of Dermatology and {dagger} Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen-Nuremberg, Erlangen, Germany

Little is known about the distinct roles of the two types of IL-4R on DC. Here we report that IL-4 and IL-13 are able to promote DC maturation, as evaluated by up-regulation of MHC class II and costimulatory molecules, when the concentration of GM-CSF is relatively lower than the dose of IL-4 or IL-13. In addition, under these conditions both cytokines enable DC to respond to maturation stimuli such as bacterial products or proinflammatory cytokines. Both IL-4 and IL-13 act synergistically with weak maturation stimuli such as TNF-{alpha} or CD40. The IL-4R signaling for DC maturation requires the IL-4R {alpha}-chain and STAT6, but not Janus kinase 3, indicating that IL-4R type II signaling is preferentially responsible for these effects. In contrast, the production of IL-12 p70, but not IL-10 and TNF, induced by microbial products was enhanced only by IL-4, not by IL-13 or Y119D, a selective type II IL-4R agonist, in vitro and in vivo. This enhancement was dependent on the presence of Janus kinase 3, indicating that this function is exclusively mediated by the type I IL-4R. In short, we discerned the individual roles of the two IL-4R types on DC function, showing that IL-4R type I promotes IL-12 secretion independently of GM-CSF concentration, while IL-4R type II promotes the up-regulation of MHC class II and costimulatory surface markers in a GM-CSF concentration-dependent manner.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. M. Dittrich, H.-C. Chen, L. Xu, P. Ranney, S. Connolly, T. O. Yarovinsky, and H. K. Bottomly
A New Mechanism for Inhalational Priming: IL-4 Bypasses Innate Immune Signals
J. Immunol., November 15, 2008; 181(10): 7307 - 7315.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Ziegler, M. Oberbarnscheidt, S. Bulfone-Paus, R. Forster, U. Kunzendorf, and S. Krautwald
CCR7 Signaling Inhibits T Cell Proliferation
J. Immunol., November 15, 2007; 179(10): 6485 - 6493.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Cortes, M. Perez-G, M. D. Rivas, and J. Zamorano
Kaempferol Inhibits IL-4-Induced STAT6 Activation by Specifically Targeting JAK3
J. Immunol., September 15, 2007; 179(6): 3881 - 3887.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J G Walker, M J Ahern, M Coleman, H Weedon, V Papangelis, D Beroukas, P J Roberts-Thomson, and M D Smith
Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis
Ann Rheum Dis, August 1, 2007; 66(8): 992 - 999.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. C. Webb, Y. Cai, K. I. Matthaei, and P. S. Foster
Comparative Roles of IL-4, IL-13, and IL-4R{alpha} in Dendritic Cell Maturation and CD4+ Th2 Cell Function
J. Immunol., January 1, 2007; 178(1): 219 - 227.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. Ziegler, F. Gueler, S. Rong, M. Mengel, O. Witzke, A. Kribben, H. Haller, U. Kunzendorf, and S. Krautwald
CCL19-IgG Prevents Allograft Rejection by Impairment of Immune Cell Trafficking
J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2521 - 2532.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. C. Morris, T. Orekhova, M. J. Meadows, S. M. Heidorn, J. Yang, and F. D. Finkelman
IL-4 Induces In Vivo Production of IFN-{gamma} by NK and NKT Cells
J. Immunol., May 1, 2006; 176(9): 5299 - 5305.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Suto, H. Nakajima, N. Tokumasa, H. Takatori, S.-i. Kagami, K. Suzuki, and I. Iwamoto
Murine Plasmacytoid Dendritic Cells Produce IFN-{gamma} upon IL-4 Stimulation
J. Immunol., November 1, 2005; 175(9): 5681 - 5689.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. S. Ahn and B. Agrawal
IL-4 is more effective than IL-13 for in vitro differentiation of dendritic cells from peripheral blood mononuclear cells
Int. Immunol., October 1, 2005; 17(10): 1337 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-L. Chu and C. A. Lowell
The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation
J. Immunol., September 1, 2005; 175(5): 2880 - 2889.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Pace, C. Pioli, and G. Doria
IL-4 Modulation of CD4+CD25+ T Regulatory Cell-Mediated Suppression
J. Immunol., June 15, 2005; 174(12): 7645 - 7653.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Padilla, E. Daley, A. Chow, K. Robinson, K. Parthasarathi, A. N. J. McKenzie, T. Tschernig, V. P. Kurup, D. D. Donaldson, and G. Grunig
IL-13 Regulates the Immune Response to Inhaled Antigens
J. Immunol., June 15, 2005; 174(12): 8097 - 8105.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Eguchi, N. Kuwashima, M. Hatano, F. Nishimura, J. E. Dusak, W. J. Storkus, and H. Okada
IL-4-Transfected Tumor Cell Vaccines Activate Tumor-Infiltrating Dendritic Cells and Promote Type-1 Immunity
J. Immunol., June 1, 2005; 174(11): 7194 - 7201.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. D. Finkelman, M. Yang, C. Perkins, K. Schleifer, A. Sproles, J. Santeliz, J. A. Bernstein, M. E. Rothenberg, S. C. Morris, and M. Wills-Karp
Suppressive Effect of IL-4 on IL-13-Induced Genes in Mouse Lung
J. Immunol., April 15, 2005; 174(8): 4630 - 4638.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Menges, T. Baumeister, S. Rossner, P. Stoitzner, N. Romani, A. Gessner, and M. B. Lutz
IL-4 supports the generation of a dendritic cell subset from murine bone marrow with altered endocytosis capacity
J. Leukoc. Biol., April 1, 2005; 77(4): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zamorano, M. D. Rivas, F. Setien, and M. Perez-G
Proteolytic Regulation of Activated STAT6 by Calpains
J. Immunol., March 1, 2005; 174(5): 2843 - 2848.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Nikolic, M. Bunk, H. A. Drexhage, and P. J. M. Leenen
Bone Marrow Precursors of Nonobese Diabetic Mice Develop into Defective Macrophage-Like Dendritic Cells In Vitro
J. Immunol., October 1, 2004; 173(7): 4342 - 4351.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-P. Liao, C.-C. Wang, L. H. Butterfield, J. S. Economou, A. Ribas, W. S. Meng, K. S. Iwamoto, and W. H. McBride
Ionizing Radiation Affects Human MART-1 Melanoma Antigen Processing and Presentation by Dendritic Cells
J. Immunol., August 15, 2004; 173(4): 2462 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Brandt, S. Bulfone-Paus, D. C. Foster, and R. Ruckert
Interleukin-21 inhibits dendritic cell activation and maturation
Blood, December 1, 2003; 102(12): 4090 - 4098.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.