| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology, Duke University Medical Center, Durham, NC 27710
The goal of infant immunization against viral infection is to
develop protective long term memory responses. Priming neonatal mice
with a low dose of Cas-Br-E murine leukemia virus (Cas) results in
adult-like, type 1 protective responses. However, other studies suggest
that Ag priming of neonates leads to an increase in type 2 secondary
responses even when primary responses were type 1. We assessed whether
type 1 CD8+ T cell-mediated responses developed in murine
neonates are maintained after secondary challenge with Cas in
adulthood. Despite the induction of significant anti-viral
CD8+-mediated cytotoxic T lymphocyte and IFN-
responses,
initial neonatal priming led to a lower frequency of virus-specific T
cells compared with adult priming. Adult frequencies were reached in
mice primed as neonates only after secondary challenge in adulthood. A
nonspecific and transient CD4+-mediated IL-4 response was
present in all groups after secondary challenge with Cas or medium,
indicating that this rise in type 2 cytokine production was not unique
to mice that had been primed as neonates. Rather, type 1 anti-viral
memory CD8+ T cell responses developed in neonatal mice are
stable, protective, and enhanced after secondary
challenge.
This article has been cited by other articles:
|
|
 |
|
  S. A. Fadel, L. G. Cowell, S. Cao, D. A. Ozaki, T. B. Kepler, D. A. Steeber, and M. Sarzotti Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection Int. Immunol., February 1, 2006; 18(2): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Caprio-Young, J. J. Bell, H.-H. Lee, J. Ellis, D. Nast, G. Sayler, B. Min, and H. Zaghouani Neonatally Primed Lymph Node, but Not Splenic T Cells, Display a Gly-Gly Motif within the TCR {beta}-Chain Complementarity-Determining Region 3 That Controls Affinity and May Affect Lymphoid Organ Retention J. Immunol., January 1, 2006; 176(1): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Regner, X. Martinez, E. Belnoue, C.-M. Sun, F. Boisgerault, P.-H. Lambert, C. Leclerc, and C.-A. Siegrist Partial Activation of Neonatal CD11c+ Dendritic Cells and Induction of Adult-Like CD8+ Cytotoxic T Cell Responses by Synthetic Microspheres J. Immunol., August 15, 2004; 173(4): 2669 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Adams, N. Nagy, F. Paulart, M.-L. Vanderhaeghen, M. Goldman, and V. Flamand CD8+ T Lymphocytes Regulating Th2 Pathology Escape Neonatal Tolerization J. Immunol., November 15, 2003; 171(10): 5071 - 5076. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
