The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, H.
Right arrow Articles by Reid, K. B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clark, H.
Right arrow Articles by Reid, K. B. M.
The Journal of Immunology, 2002, 169: 2892-2899.
Copyright © 2002 by The American Association of Immunologists

Surfactant Protein D Reduces Alveolar Macrophage Apoptosis In Vivo1

Howard Clark2,*, Nades Palaniyar*, Peter Strong*, Jess Edmondson{dagger}, Samuel Hawgood{dagger} and Kenneth B. M. Reid*

* Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom; and {dagger} Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, CA 94143

Surfactant protein D (SP-D) is a molecule of the innate immune system that recognizes the patterns of surface carbohydrate on pathogens and targets them for phagocytosis and killing. SP-D-deficient mice show an increased number of macrophages in the alveolar space, excess surfactant phospholipid, overproduction of reactive oxygen species, and the development of emphysema. We report here that SP-D-deficient mice have a 5- to 10-fold increase in the number of apoptotic and necrotic alveolar macrophages, as defined by annexin V and propidium iodine staining, respectively. Intrapulmonary administration of a truncated 60-kDa fragment of human recombinant SP-D reduces the number of apoptotic and necrotic alveolar macrophages and partially corrects the lipid accumulation in SP-D-deficient mice. The same SP-D fragment binds preferentially to apoptotic and necrotic alveolar macrophages in vitro, suggesting that SP-D contributes to immune homeostasis in the lung by recognizing and promoting removal of necrotic and apoptotic cells.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Jain, E. N. Atochina-Vasserman, Y. Tomer, H. Kadire, and M. F. Beers
Surfactant Protein D Protects against Acute Hyperoxic Lung Injury
Am. J. Respir. Crit. Care Med., October 15, 2008; 178(8): 805 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Mahajan, T. Madan, N. Kamal, V. K. Singh, R. B. Sim, S. D. Telang, C. N. Ramchand, P. Waters, U. Kishore, and P. U. Sarma
Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages
Int. Immunol., August 1, 2008; 20(8): 993 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. J. Janssen, K. A. McPhillips, M. G. Dickinson, D. J. Linderman, K. Morimoto, Y. Q. Xiao, K. M. Oldham, R. W. Vandivier, P. M. Henson, and S. J. Gardai
Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRP{alpha}
Am. J. Respir. Crit. Care Med., July 15, 2008; 178(2): 158 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Therapeutic Advances in Respiratory DiseaseHome page
D. D. Sin, P. S. Pahlavan, and S.F. P. Man
Review: Surfactant protein D: A lung specific biomarker in COPD?
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 65 - 74.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
E. N. Atochina-Vasserman, M. F. Beers, H. Kadire, Y. Tomer, A. Inch, P. Scott, C. J. Guo, and A. J. Gow
Selective Inhibition of Inducible NO Synthase Activity In Vivo Reverses Inflammatory Abnormalities in Surfactant Protein D-Deficient Mice
J. Immunol., December 15, 2007; 179(12): 8090 - 8097.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Jain, E. Atochina-Vasserman, H. Kadire, Y. Tomer, A. Inch, P. Scott, R. C. Savani, A. J. Gow, and M. F. Beers
SP-D-deficient mice are resistant to hyperoxia
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L861 - L871.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. P. Senft, T. R. Korfhagen, J. A. Whitsett, and A. M. LeVine
Surfactant protein D regulates the cell surface expression of alveolar macrophage beta2-integrins
Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L469 - L475.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. S. Kingma, L. Zhang, M. Ikegami, K. Hartshorn, F. X. McCormack, and J. A. Whitsett
Correction of Pulmonary Abnormalities in Sftpd-/- Mice Requires the Collagenous Domain of Surfactant Protein D
J. Biol. Chem., August 25, 2006; 281(34): 24496 - 24505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Zhang, M. Ikegami, T. R. Korfhagen, F. X. McCormack, M. Yoshida, R. M. Senior, J. M. Shipley, S. D. Shapiro, and J. A. Whitsett
Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis
Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L181 - L190.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Morimoto, W. J. Janssen, M. B. Fessler, K. A. McPhillips, V. M. Borges, R. P. Bowler, Y.-Q. Xiao, J. A. Kench, P. M. Henson, and R. W. Vandivier
Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease.
J. Immunol., June 15, 2006; 176(12): 7657 - 7665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Ikegami, K. Carter, K. Bishop, A. Yadav, E. Masterjohn, W. Brondyk, R. K. Scheule, and J. A. Whitsett
Intratracheal Recombinant Surfactant Protein D Prevents Endotoxin Shock in the Newborn Preterm Lamb
Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1342 - 1347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. L. Sorensen, J. Madsen, K. Kejling, I. Tornoe, O. Nielsen, P. Townsend, F. Poulain, C. H. Nielsen, K. B. M. Reid, S. Hawgood, et al.
Surfactant protein D is proatherogenic in mice
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2286 - H2294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. L. Sorensen, J. v. B. Hjelmborg, K. O. Kyvik, M. Fenger, A. Hoj, C. Bendixen, T. I. A. Sorensen, and U. Holmskov
Genetic and environmental influences of surfactant protein D serum levels
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1010 - L1017.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
W. Khamri, A. P. Moran, M. L. Worku, Q. N. Karim, M. M. Walker, H. Annuk, J. A. Ferris, B. J. Appelmelk, P. Eggleton, K. B. M. Reid, et al.
Variations in Helicobacter pylori Lipopolysaccharide To Evade the Innate Immune Component Surfactant Protein D
Infect. Immun., November 1, 2005; 73(11): 7677 - 7686.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
J. Meschi, E. C. Crouch, P. Skolnik, K. Yahya, U. Holmskov, R. Leth-Larsen, I. Tornoe, T. Tecle, M. R. White, and K. L. Hartshorn
Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication
J. Gen. Virol., November 1, 2005; 86(11): 3097 - 3107.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Casey, J. Kaplan, E. N. Atochina-Vasserman, A. J. Gow, H. Kadire, Y. Tomer, J. H. Fisher, S. Hawgood, R. C. Savani, and M. F. Beers
Alveolar Surfactant Protein D Content Modulates Bleomycin-induced Lung Injury
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 869 - 877.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K B M Reid, H Clark, and N Palaniyar
Surfactant and lung inflammation
Thorax, August 1, 2005; 60(8): 620 - 622.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Palaniyar, H. Clark, J. Nadesalingam, M. J. Shih, S. Hawgood, and K. B. M. Reid
Innate Immune Collectin Surfactant Protein D Enhances the Clearance of DNA by Macrophages and Minimizes Anti-DNA Antibody Generation
J. Immunol., June 1, 2005; 174(11): 7352 - 7358.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Betsuyaku, Y. Kuroki, K. Nagai, Y. Nasuhara, and M. Nishimura
Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid
Eur. Respir. J., December 1, 2004; 24(6): 964 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Dave, T. Childs, and J. A. Whitsett
Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells
J. Biol. Chem., August 13, 2004; 279(33): 34578 - 34588.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Palaniyar, J. Nadesalingam, H. Clark, M. J. Shih, A. W. Dodds, and K. B. M. Reid
Nucleic Acid Is a Novel Ligand for Innate, Immune Pattern Recognition Collectins Surfactant Proteins A and D and Mannose-binding Lectin
J. Biol. Chem., July 30, 2004; 279(31): 32728 - 32736.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. P. Hickling, H. Clark, R. Malhotra, and R. B. Sim
Collectins and their role in lung immunity
J. Leukoc. Biol., January 1, 2004; 75(1): 27 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
H Clark and K Reid
The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema
Arch. Dis. Child., November 1, 2003; 88(11): 981 - 984.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Takeda, N. Miyahara, Y.-H. Rha, C. Taube, E.-S. Yang, A. Joetham, T. Kodama, A. M. Balhorn, A. Dakhama, C. Duez, et al.
Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. F. Reidy and J. R. Wright
Surfactant protein A enhances apoptotic cell uptake and TGF-{beta}1 release by inflammatory alveolar macrophages
Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L854 - L861.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Nadesalingam, A. L. Bernal, A. W. Dodds, A. C. Willis, D. J. Mahoney, A. J. Day, K. B. M. Reid, and N. Palaniyar
Identification and Characterization of a Novel Interaction between Pulmonary Surfactant Protein D and Decorin
J. Biol. Chem., July 3, 2003; 278(28): 25678 - 25687.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.